Pegfilgrastim after high-dose chemotherapy and autologous peripheral blood stem cell transplant: Phase II study

Madan H. Jagasia, J. P. Greer, D. S. Morgan, S. Mineishi, A. A. Kassim, K. L. Ruffner, H. Chen, F. G. Schuening

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40 Scopus citations


Pegfilgrastim is equivalent to daily filgrastim after standard dose chemotherapy in decreasing the duration of neutropenia. Daily filgrastim started within 1-4 days after autologous stem cell transplant (ASCT) leads to significant decrease in time to neutrophil engraftment. We undertook a study of pegfilgrastim after high-dose chemotherapy (HDC) and ASCT. In all, 38 patients with multiple myeloma or lymphoma, eligible to undergo HDC and ASCT, were enrolled. Patients received a single dose of 6mg pegfilgrastim subcutaneously 24h after ASCT. There were no adverse events secondary to pegfilgrastim. All patients engrafted neutrophils and platelets with a median of 10 and 18 days, respectively. The incidence of febrile neutropenia was 49% (18/37). Neutrophil engraftment results were compared to a historical cohort of patients who received no growth factors or prophylactic filgrastim after ASCT. Time to neutrophil engraftment using pegfilgrastim was comparable to daily filgrastim and was shorter than in a historical group receiving no filgrastim (10 vs 13.7 days, P < 0.001). Pegfilgrastim given as a single fixed dose of 6 mg appears to be safe after HDC and ASCT. It accelerates neutrophil engraftment comparable to daily filgrastim after ASCT. Pegfilgrastim may be convenient to use in outpatient transplant units.

Original languageEnglish (US)
Pages (from-to)1165-1169
Number of pages5
JournalBone Marrow Transplantation
Issue number12
StatePublished - Jun 2005

All Science Journal Classification (ASJC) codes

  • Hematology
  • Transplantation


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