TY - JOUR
T1 - Penicillin-Resistant Streptococcus pneumoniae Strains Recovered in Houston
T2 - Identification and Molecular Characterization of Multiple Clones
AU - Versalovic, James
AU - Kapur, Vivek
AU - Mason, Edward O.
AU - Shah, Urna
AU - Koeuth, Thearith
AU - Lupski, James R.
AU - Musser, James M.
N1 - Funding Information:
Financial support: National Institutes of Health (RR-05425, AI-33l19 [to J.M.M.J, and Medical Scientist Training Program and Minority Predoctoral Fellowship Program [to J.V.]); Texas Higher Education Advanced Technology Program and Pew Scholars Program in Biomedical Sciences (to J.R.L.).
PY - 1993/4
Y1 - 1993/4
N2 - A sample of 48 penicillin-resistant Streptococcus pneumoniae (PRSP) strains recovered between January 1989 and May 1991, primarily from infected children in Houston, was characterized by multilocus enzyme electrophoresis and repetitive extragenic palindromic-polymerase chain reaction genomic profiling. A heterogeneous array of 22 clonal genotypes was identified, but 64% of the PRSP strains in the sample were assigned to five clones that are closely similar in overall chromosomal character and express serotype 6 capsule. A close genetic association between these five clones and penicillin-resistant 6B clones recovered in Alaska, Iceland, and Spain was identified by multilocus enzyme electrophoresis. Taken together, the results suggest either that the common resistant 6B clones in Alaska, Iceland, Spain, and Houston have a recent ancestor or that isolates of a certain pneumococcal phylogenetic lineage are more likely to develop penicillin resistance.
AB - A sample of 48 penicillin-resistant Streptococcus pneumoniae (PRSP) strains recovered between January 1989 and May 1991, primarily from infected children in Houston, was characterized by multilocus enzyme electrophoresis and repetitive extragenic palindromic-polymerase chain reaction genomic profiling. A heterogeneous array of 22 clonal genotypes was identified, but 64% of the PRSP strains in the sample were assigned to five clones that are closely similar in overall chromosomal character and express serotype 6 capsule. A close genetic association between these five clones and penicillin-resistant 6B clones recovered in Alaska, Iceland, and Spain was identified by multilocus enzyme electrophoresis. Taken together, the results suggest either that the common resistant 6B clones in Alaska, Iceland, Spain, and Houston have a recent ancestor or that isolates of a certain pneumococcal phylogenetic lineage are more likely to develop penicillin resistance.
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U2 - 10.1093/infdis/167.4.850
DO - 10.1093/infdis/167.4.850
M3 - Article
C2 - 8450250
AN - SCOPUS:0027478539
SN - 0022-1899
VL - 167
SP - 850
EP - 856
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 4
ER -