Peptide bond formation via catalytic antibodies: Synthesis of a novel phosphonate diester hapten

Amos B. Smith; Carol M. Taylor; Stephen J. Benkovic; Ralph Hirschmann

doi:10.1016/0040-4039(94)85022-4

Peptide bond formation via catalytic antibodies: Synthesis of a novel phosphonate diester hapten

Amos B. Smith, Carol M. Taylor, Stephen J. Benkovic, Ralph Hirschmann

Chemistry

Research output: Contribution to journal › Article › peer-review

92 Scopus citations

Abstract

Phosphonate diester 2, a hapten recently employed to induce the first monoclonal catalytic antibodies capable of catalyzing peptide bond formation, was synthesized via elaboration of scalemic α-amino phosphonate 4.

Original language	English (US)
Pages (from-to)	6853-6856
Number of pages	4
Journal	Tetrahedron Letters
Volume	35
Issue number	37
DOIs	https://doi.org/10.1016/0040-4039(94)85022-4
State	Published - Sep 12 1994

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/0040-4039(94)85022-4

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@article{7f955912dbfe4d26a06227c3d89875a2,

title = "Peptide bond formation via catalytic antibodies: Synthesis of a novel phosphonate diester hapten",

abstract = "Phosphonate diester 2, a hapten recently employed to induce the first monoclonal catalytic antibodies capable of catalyzing peptide bond formation, was synthesized via elaboration of scalemic α-amino phosphonate 4.",

author = "Smith, {Amos B.} and Taylor, {Carol M.} and Benkovic, {Stephen J.} and Ralph Hirschmann",

year = "1994",

month = sep,

day = "12",

doi = "10.1016/0040-4039(94)85022-4",

language = "English (US)",

volume = "35",

pages = "6853--6856",

journal = "Tetrahedron Letters",

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number = "37",

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TY - JOUR

T1 - Peptide bond formation via catalytic antibodies

T2 - Synthesis of a novel phosphonate diester hapten

AU - Smith, Amos B.

AU - Taylor, Carol M.

AU - Benkovic, Stephen J.

AU - Hirschmann, Ralph

PY - 1994/9/12

Y1 - 1994/9/12

N2 - Phosphonate diester 2, a hapten recently employed to induce the first monoclonal catalytic antibodies capable of catalyzing peptide bond formation, was synthesized via elaboration of scalemic α-amino phosphonate 4.

AB - Phosphonate diester 2, a hapten recently employed to induce the first monoclonal catalytic antibodies capable of catalyzing peptide bond formation, was synthesized via elaboration of scalemic α-amino phosphonate 4.

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UR - http://www.scopus.com/inward/citedby.url?scp=0027982561&partnerID=8YFLogxK

U2 - 10.1016/0040-4039(94)85022-4

DO - 10.1016/0040-4039(94)85022-4

M3 - Article

AN - SCOPUS:0027982561

SN - 0040-4039

VL - 35

SP - 6853

EP - 6856

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 37

ER -

Peptide bond formation via catalytic antibodies: Synthesis of a novel phosphonate diester hapten

Abstract

All Science Journal Classification (ASJC) codes

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