Peptide Design and Self-assembly into Targeted Nanostructure and Functional Materials

Nairiti J. Sinha, Matthew G. Langenstein, Darrin J. Pochan, Christopher J. Kloxin, Jeffery G. Saven

Research output: Contribution to journalReview articlepeer-review

143 Scopus citations

Abstract

Peptides have been extensively utilized to construct nanomaterials that display targeted structure through hierarchical assembly. The self-assembly of both rationally designed peptides derived from naturally occurring domains in proteins as well as intuitively or computationally designed peptides that form β-sheets and helical secondary structures have been widely successful in constructing nanoscale morphologies with well-defined 1-d, 2-d, and 3-d architectures. In this review, we discuss these successes of peptide self-assembly, especially in the context of designing hierarchical materials. In particular, we emphasize the differences in the level of peptide design as an indicator of complexity within the targeted self-assembled materials and highlight future avenues for scientific and technological advances in this field.

Original languageEnglish (US)
Pages (from-to)13915-13935
Number of pages21
JournalChemical Reviews
Volume121
Issue number22
DOIs
StatePublished - Nov 24 2021

All Science Journal Classification (ASJC) codes

  • General Chemistry

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