Abstract
Unlike the polymorphic MHC class Ia molecules, MHC class Ib molecules are oligomorphic or nonpolymorphic. We recently discovered a protective CD8 T cell response to mouse polyomavirus (MPyV) in H-2b haplotype mice that is restricted by H2-Q9, a member of the Qa-2 MHC class Ib family. Here, we demonstrate that immunization with a peptide corresponding to a virus capsid-derived peptide presented by Q9 also elicits MHC class Ib-restricted MPyV-specific CD8 T cells in mice of H-2s and H-2g7 strains. These findings support the concept that immunization with a single MHC class Ib-restricted peptide can expand CD8 T cells in MHC class Ia allogeneic hosts.
Original language | English (US) |
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Pages (from-to) | 109-113 |
Number of pages | 5 |
Journal | Viral Immunology |
Volume | 26 |
Issue number | 1 |
DOIs | |
State | Published - Feb 1 2013 |
All Science Journal Classification (ASJC) codes
- Immunology
- Molecular Medicine
- Virology