Performance of some multiple testing procedures to compare three doses of a test drug and placebo

Lan Kong, Gary Koch, Thomas Liu, Huei Wang

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


A study design with two or more doses of a test drug and placebo is frequently used in clinical drug development. Multiplicity issues arise when there are multiple comparisons between doses of test drug and placebo, and also when there are comparisons of doses with one another. An appropriate analysis strategy needs to be specified in advance to avoid spurious results through insufficient control of Type I error, as well as to avoid the loss of power due to excessively conservative adjustments for multiplicity. For evaluation of alternative strategies with possibly complex management of multiplicity, we compare the performance of several testing procedures through the simulated data that represent various patterns of treatment differences. The purpose is to identify which methods perform better or more robustly than the others and under what conditions.

Original languageEnglish (US)
Pages (from-to)25-35
Number of pages11
JournalPharmaceutical Statistics
Issue number1
StatePublished - Jan 2005

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Pharmacology
  • Pharmacology (medical)


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