Peri-adolescent asthma: Acute impacts on innate immune response, corticosterone, and microglia in mice

Jasmine I. Caulfield; Kerri J. Schopf; Sonia A. Cavigelli

doi:10.1016/j.jneuroim.2020.577450

Peri-adolescent asthma: Acute impacts on innate immune response, corticosterone, and microglia in mice

Jasmine I. Caulfield, Kerri J. Schopf, Sonia A. Cavigelli

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Asthma is highly comorbid with anxiety in youth. We investigated the hypothalamic-pituitary-adrenal (HPA) axis and microglia as mechanisms underlying asthma and anxiety comorbidity. We induced asthma symptoms in developing BALB/cJ mice with house dust mite (HDM) for airway inflammation and methacholine (MCH) for bronchoconstriction. On the last day of exposure, we analyzed samples at six timepoints. Lung IL-5 and IL-1β expression peaked 4 h after final HDM exposure. Circulating corticosterone was blunted in a sex- and treatment-specific temporal pattern. Hippocampal IL-1β expression and microglial area were marginally increased 24 h after MCH exposure. These results provide a foundation for further work investigating asthma-anxiety mechanisms.

Original language	English (US)
Article number	577450
Journal	Journal of Neuroimmunology
Volume	350
DOIs	https://doi.org/10.1016/j.jneuroim.2020.577450
State	Published - Jan 15 2021

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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title = "Peri-adolescent asthma: Acute impacts on innate immune response, corticosterone, and microglia in mice",

abstract = "Asthma is highly comorbid with anxiety in youth. We investigated the hypothalamic-pituitary-adrenal (HPA) axis and microglia as mechanisms underlying asthma and anxiety comorbidity. We induced asthma symptoms in developing BALB/cJ mice with house dust mite (HDM) for airway inflammation and methacholine (MCH) for bronchoconstriction. On the last day of exposure, we analyzed samples at six timepoints. Lung IL-5 and IL-1β expression peaked 4 h after final HDM exposure. Circulating corticosterone was blunted in a sex- and treatment-specific temporal pattern. Hippocampal IL-1β expression and microglial area were marginally increased 24 h after MCH exposure. These results provide a foundation for further work investigating asthma-anxiety mechanisms.",

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T1 - Peri-adolescent asthma

T2 - Acute impacts on innate immune response, corticosterone, and microglia in mice

AU - Caulfield, Jasmine I.

AU - Schopf, Kerri J.

AU - Cavigelli, Sonia A.

PY - 2021/1/15

Y1 - 2021/1/15

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AB - Asthma is highly comorbid with anxiety in youth. We investigated the hypothalamic-pituitary-adrenal (HPA) axis and microglia as mechanisms underlying asthma and anxiety comorbidity. We induced asthma symptoms in developing BALB/cJ mice with house dust mite (HDM) for airway inflammation and methacholine (MCH) for bronchoconstriction. On the last day of exposure, we analyzed samples at six timepoints. Lung IL-5 and IL-1β expression peaked 4 h after final HDM exposure. Circulating corticosterone was blunted in a sex- and treatment-specific temporal pattern. Hippocampal IL-1β expression and microglial area were marginally increased 24 h after MCH exposure. These results provide a foundation for further work investigating asthma-anxiety mechanisms.

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Peri-adolescent asthma: Acute impacts on innate immune response, corticosterone, and microglia in mice

Abstract

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