Perioperative Aspirin Use Is Associated with Bleeding Complications during Robotic Partial Nephrectomy

Joan C. Delto, Aaron Fleishman, Peter Chang, Jiang Da David, Sara Hyde, Kyle McAnally, Catrina Crociani, Marcus Jamil, Hiten D. Patel, Jonathan Pavlinec, Jeffrey Budzyn, Adri Durant, Benjamin Eilender, Ashley O. Gordon, Mitchell M. Huang, Phillip M. Pierorazio, Jay D. Raman, Craig Rogers, Li Ming Su, Andrew A. Wagner

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Purpose: Daily aspirin use following cardiovascular intervention is commonplace and creates concern regarding bleeding risk in patients undergoing surgery. Despite its cardio-protective role, aspirin is often discontinued 5e7 days prior to major surgery due to bleeding concerns. Single institution studies have investigated perioperative outcomes of aspirin use in robotic partial nephrectomy (RPN). We sought to evaluate the outcomes of perioperative aspirin (pASA) use during RPN in a multicenter setting. Materials and Methods: We performed a retrospective evaluation of patients undergoing RPN at 5 high volume RPN institutions. We compared perioperative outcomes of patients taking pASA (81 mg) to those not on aspirin. We analyzed the association between pASA use and perioperative transfusion. Results: Of 1,565 patients undergoing RPN, 228 (14.5%) patients continued pASA and were older (62.8 vs 56.8 years, p <0.001) with higher Charlson scores (mean 3 vs 2, p <0.001). pASA was associated with increased perioperative blood transfusions (11% vs 4%, p <0.001) and major complications (10% vs 3%, p <0.001). On multivariable analysis, pASA was associated with increased transfusion risk (OR 1.94, 1.10e3.45, 95% CI). Conclusions: In experienced hands, perioperative aspirin 81 mg use during RPN is reasonable and safe; however, there is a higher risk of blood transfusions and major complications. Future studies are needed to clarify the role of antiplatelet therapy in RPN patients requiring pASA for primary or secondary prevention of cardiovascular events.

Original languageEnglish (US)
Pages (from-to)277-283
Number of pages7
JournalJournal of Urology
Issue number2
StatePublished - Feb 1 2022

All Science Journal Classification (ASJC) codes

  • Urology


Dive into the research topics of 'Perioperative Aspirin Use Is Associated with Bleeding Complications during Robotic Partial Nephrectomy'. Together they form a unique fingerprint.

Cite this