TY - JOUR
T1 - Peripheral zinc and neopterin concentrations are associated with mood severity in bipolar disorder in a gender-specific manner
AU - Millett, Caitlin E.
AU - Mukherjee, Dahlia
AU - Reider, Aubrey
AU - Can, Adem
AU - Groer, Maureen
AU - Fuchs, Dietmar
AU - Postolache, Teodor T.
AU - Kelleher, Shannon L.
AU - Saunders, Erika F.H.
N1 - Publisher Copyright:
© 2017 Elsevier Ireland Ltd
PY - 2017/9
Y1 - 2017/9
N2 - Bipolar disorder (BD) is a recurrent, episodic mood disorder for which there are no current diagnostic, prognostic or theranostic biomarkers. Two peripheral markers of the acute phase immune response, zinc and neopterin, are consistently associated with severity of depression in literature. Given gender differences in clinical presentation of BD and in inflammatory processes, we aimed to explore the interaction between gender and immune biomarkers to predict mood severity in BD. Participants with DSM IV BD I and II were recruited through the Pennsylvania Psychiatric Institute during an acute mood episode. Healthy controls (HC) were recruited through advertisements. Participants fasted for at least 6 h when blood was drawn for biomarkers. We found that zinc concentrations were significantly lower in the BD group at baseline (p<.05), and there was also a significant interaction between gender and zinc (p<.05), associated with depression severity. Also, we found a significant interaction between gender and neopterin, associated with mania severity (p<.05). We found that mania severity was associated with neopterin in men, while depression severity was positively associated with zinc in women. Our report bears replication in larger samples and highlights the potential for differences in the underlying pathophysiology between men and women with BD.
AB - Bipolar disorder (BD) is a recurrent, episodic mood disorder for which there are no current diagnostic, prognostic or theranostic biomarkers. Two peripheral markers of the acute phase immune response, zinc and neopterin, are consistently associated with severity of depression in literature. Given gender differences in clinical presentation of BD and in inflammatory processes, we aimed to explore the interaction between gender and immune biomarkers to predict mood severity in BD. Participants with DSM IV BD I and II were recruited through the Pennsylvania Psychiatric Institute during an acute mood episode. Healthy controls (HC) were recruited through advertisements. Participants fasted for at least 6 h when blood was drawn for biomarkers. We found that zinc concentrations were significantly lower in the BD group at baseline (p<.05), and there was also a significant interaction between gender and zinc (p<.05), associated with depression severity. Also, we found a significant interaction between gender and neopterin, associated with mania severity (p<.05). We found that mania severity was associated with neopterin in men, while depression severity was positively associated with zinc in women. Our report bears replication in larger samples and highlights the potential for differences in the underlying pathophysiology between men and women with BD.
UR - https://www.scopus.com/pages/publications/85019392441
UR - https://www.scopus.com/inward/citedby.url?scp=85019392441&partnerID=8YFLogxK
U2 - 10.1016/j.psychres.2017.05.022
DO - 10.1016/j.psychres.2017.05.022
M3 - Article
C2 - 28528241
AN - SCOPUS:85019392441
SN - 0165-1781
VL - 255
SP - 52
EP - 58
JO - Psychiatry Research
JF - Psychiatry Research
ER -
