PERK (eIF2α kinase) is required to activate the stress-activated MAPKs and induce the expression of immediate-early genes upon disruption of ER calcium homoeostasis

Keyphrases

• Endoplasmic Reticulum 100%
• Unfolded Protein Response 100%
• Calcium Homeostasis 100%
• P38 Mitogen-activated Protein Kinase (p38 MAPK) 100%
• EIF2α Kinase 100%
• Immediate-early Gene 100%
• Endoplasmic Reticulum Calcium 100%
• Mouse Embryonic Fibroblasts 66%
• C-Jun N-terminal Kinase 66%
• Endoplasmic Reticulum Stress (ER stress) 66%
• Thapsigargin 66%
• C-Myc 66%
• Early Growth Response Protein 1 (EGR1) 66%
• Tumor Necrosis Factor-α 33%
• Transmembrane 33%
• Major Components 33%
• Mitogen-activated Protein Kinase 33%
• Phosphoinositide 3-kinase (PI3K) 33%
• Global Change 33%
• Stress-responsive Genes 33%
• Endoplasmic Reticulum Ca2+ 33%
• Dependent Stress 33%
• Pancreas 33%
• Gene Expression Profiling 33%
• Mammalian Cells 33%
• Cellular Response 33%
• EIF2 33%
• Gene-deficient Mice 33%
• Ca2+-ATPase 33%
• Phospholipase C 33%
• Dithiothreitol 33%
• Calcium Pump 33%
• Physiological Function 33%
• UV Radiation 33%
• Calcium-binding Proteins 33%
• MYC Expression 33%
• C-Jun 33%
• Double-stranded RNA-dependent Protein Kinase 33%
• Normal Function 33%
• Anisomycin 33%
• Tunicamycin 33%
• Variable Dependency 33%
• Stress Stimuli 33%
• Changes in Gene Expression 33%
• Secretory Cells 33%
• EIF2a 33%
• Skeletal System 33%

Biochemistry, Genetics and Molecular Biology

• Kinase 100%
• Phosphotransferase 100%
• Mitogen-Activated Protein Kinase 100%
• Immediate Early Gene 100%
• Calcium Homeostasis 100%
• Unfolded Protein Response 60%
• Oncogene C Myc 60%
• P38 Mitogen-Activated Protein Kinases 60%
• Endoplasmic Reticulum Stress 40%
• N-Terminus 40%
• Early Growth Response Factor 1 40%
• Gene Expression 20%
• Enzyme 20%
• Phosphoinositide 3-Kinase 20%
• Eukaryotic Initiation Factor 20%
• Dithiothreitol 20%
• Tumor Necrosis Factor Alpha 20%
• Protein Kinase R 20%
• Tunicamycin 20%
• Calcium ATPase 20%