Peroxisome proliferator-activated receptor-δ attenuates colon carcinogenesis

Fred S. Harman, Christopher J. Nicol, Holly E. Marin, Jerrold M. Ward, Frank J. Gonzalez, Jeffrey M. Peters

Research output: Contribution to journalArticlepeer-review

189 Scopus citations


Peroxisome proliferator-activated receptor-δ (PPAR-δ; also known as PPAR-β) is expressed at high levels in colon tumors, but its contribution to colon cancer is unclear. We examined the role of PPAR-δ in colon carcinogenesis using PPAR-δ-deficient (Ppard-/-) mice. In both the Min mutant and chemically induced mouse models, colon polyp formation was significantly greater in mice nullizygous for PPAR-δ. In contrast to previous reports suggesting that activation of PPAR-δ potentiates colon polyp formation, here we show that PPAR-δ attenuates colon carcinogenesis.

Original languageEnglish (US)
Pages (from-to)481-483
Number of pages3
JournalNature Medicine
Issue number5
StatePublished - May 2004

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)


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