TY - JOUR
T1 - Pharmacokinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Seveso adults and veterans of operation Ranch Hand
AU - Michalek, Joel E.
AU - Pirkle, James L.
AU - Needham, Larry L.
AU - Patterson, Donald G.
AU - Caudill, Samuel P.
AU - Tripathi, Ram C.
AU - Mocarelli, Paolo
N1 - Funding Information:
The authors thank the staff at the Human Systems Center, Brooks Air Force Base, for their support. Professor Mocarelli was partially supported by Grant No. 2896 from Regione Lombardia and by a grant from Fondazione Lombardia Ambiente, Milan, Italy.
PY - 2002
Y1 - 2002
N2 - A combined analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) elimination in Seveso adults and Ranch Hand veterans found a period of fast elimination within the first 0.27 years after exposure in Seveso, followed by a period of slower elimination between 3 and 16.35 years from exposure. The mean TCDD elimination rate within the first 0.27 years after exposure among six adult males in the Seveso cohort was 2.0646 year-1 (half-life =0.34 years). The mean rate from 3 to 16.35 years was 0.1011 year-1 (half-life=6.9 years). The mean Ranch Hand elimination rate, 00924 year-1 (half-life=6.9 years), measured between 9 and 33 years after exposure, was significantly less than the Seveso mean in the first 0.27 years after exposure, but not significantly different from the Seveso mean between 3 and 16.35 years after exposure. The fast elimination within the first 0.27 years followed by a slower rate after 3 years is consistent with the expected pattern in a two-compartment open model, with a distribution phase of rapid elimination followed by a slower elimination phase.
AB - A combined analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) elimination in Seveso adults and Ranch Hand veterans found a period of fast elimination within the first 0.27 years after exposure in Seveso, followed by a period of slower elimination between 3 and 16.35 years from exposure. The mean TCDD elimination rate within the first 0.27 years after exposure among six adult males in the Seveso cohort was 2.0646 year-1 (half-life =0.34 years). The mean rate from 3 to 16.35 years was 0.1011 year-1 (half-life=6.9 years). The mean Ranch Hand elimination rate, 00924 year-1 (half-life=6.9 years), measured between 9 and 33 years after exposure, was significantly less than the Seveso mean in the first 0.27 years after exposure, but not significantly different from the Seveso mean between 3 and 16.35 years after exposure. The fast elimination within the first 0.27 years followed by a slower rate after 3 years is consistent with the expected pattern in a two-compartment open model, with a distribution phase of rapid elimination followed by a slower elimination phase.
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U2 - 10.1038/sj/jea/7500201
DO - 10.1038/sj/jea/7500201
M3 - Article
C2 - 11859432
AN - SCOPUS:0036175569
SN - 1053-4245
VL - 12
SP - 44
EP - 53
JO - Journal of Exposure Analysis and Environmental Epidemiology
JF - Journal of Exposure Analysis and Environmental Epidemiology
IS - 1
ER -
