Pharmacologic manipulation of sphingosine kinase in retinal endothelial cells: Implications for angiogenic ocular diseases

Keyphrases

• Adhesion Proteins 11%
• Age-related Macular Degeneration 11%
• Angiogenesis 22%
• Angiogenic 100%
• Cell Proliferation 11%
• Diabetic Retinopathy 44%
• Diabetic Retinopathy Treatment 11%
• Etiology 11%
• Immunoblot Analysis 11%
• In Vivo Assay 11%
• In Vivo Model 11%
• Increased Vascular Permeability 11%
• Induced Expression 11%
• Induced Production 11%
• Induced Proliferation 11%
• Inflammatory Stimuli 11%
• Kinase Activity 11%
• Local Inflammation 11%
• Mediating Response 11%
• Ocular Diseases 100%
• Pharmacologic 100%
• Pharmacological Inhibitors 11%
• Retinal Endothelial Cells 100%
• Sphingosine Kinase 1 (SphK1) 100%
• Sphingosine Kinase Inhibitor 22%
• Sphingosine-1-phosphate 11%
• Streptozotocin-induced 11%
• Therapeutic Efficacy 11%
• Tumor Necrosis Factor-α 44%
• Vascular Endothelial Growth Factor 88%
• Vascular Leakage 11%

Pharmacology, Toxicology and Pharmaceutical Science

• Age Related Macular Degeneration 11%
• Combination Therapy 11%
• Diabetic Retinopathy 55%
• Diseases 11%
• Eye Disease 100%
• Inflammation 11%
• Mouse Model 11%
• Sphingosine 1 Phosphate 11%
• Sphingosine Kinase 100%
• Sphingosine Kinase Inhibitor 22%
• Streptozotocin 11%
• Tumor Necrosis Factor 44%
• Vasculotropin 88%
• Western Blot 11%

Neuroscience

• Age-Related Macular Degeneration 9%
• Angiogenesis 18%
• Blood Vessel Permeability 9%
• Cell Proliferation 9%
• Diabetic Retinopathy 45%
• In Vitro 9%
• In Vivo 27%
• Necrosis 36%
• Ophthalmic Disorder 100%
• Sphingosine 1 Phosphate 9%
• Sphingosine Kinase 100%
• Streptozotocin 9%
• Vascular Endothelial Growth Factor 72%