Phase II study of oxaliplatin as second-line chemotherapy in endometrial carcinoma: A Gynecologic Oncology Group study

Paula M. Fracasso, John A. Blessing, Kelly L. Molpus, Lisa M. Adler, Joel I. Sorosky, Peter G. Rose

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


Objective.: A phase II study was conducted to determine the efficacy of oxaliplatin therapy in patients with advanced or recurrent endometrial cancer who had received one prior platinum therapy. Methods.: Eligible patients were to have measurable disease and one prior chemotherapy regimen which could include cisplatin or carboplatin. Oxaliplatin 130 mg/m2 was administered intravenously over 2 h. This treatment was repeated every 21 days until progression of disease or adverse effects prohibited further therapy. Results.: Fifty-four patients were entered on study, of which 52 were eligible and 50 had had prior platinum therapy. The overall response rate was 13.5%, with three patients (5.8%) achieving a complete response and four patients (7.7%) achieving a partial response. Median duration of response was 10.9+ (range: 4.1-50.3+) months. Stable disease was reported in 15 (28.8%) patients, with an associated median duration of 5.4 (range: 2.2-19.6) months. Drug-related toxicities consisted of anemia, nausea and vomiting, and neurotoxicity. Conclusions.: Oxaliplatin at the dose and schedule employed has limited activity in patients with advanced or recurrent endometrial carcinoma who have had previous platinum therapy.

Original languageEnglish (US)
Pages (from-to)523-526
Number of pages4
JournalGynecologic Oncology
Issue number2
StatePublished - Nov 2006

All Science Journal Classification (ASJC) codes

  • Oncology
  • Obstetrics and Gynecology

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