Phase II trial of 5 day continuous intravenous infusion of 6-thioguanine in patients with recurrent and metastatic squamous cell carcinoma of the head and neck

Flavio Kruter; Mario Eisenberger; Victoria Sinibaldi; Christine Engstrom; Maria Jacobs; Jeffrey Abrams; Chandra Belani; William Gray; Steven Krasnow

doi:10.1007/BF00873122

Phase II trial of 5 day continuous intravenous infusion of 6-thioguanine in patients with recurrent and metastatic squamous cell carcinoma of the head and neck

Flavio Kruter
, Mario Eisenberger
, Victoria Sinibaldi
, Christine Engstrom
, Maria Jacobs
, Jeffrey Abrams
, Chandra Belani
, William Gray
, Steven Krasnow

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Fifteen patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck received a 5 day continuous I.V. infusion of 6-thioguanine repeated every five weeks. Dose limiting toxicity was primarily hematological with grade III/IV leucopenia and thrombocytopenia seen in seven patients. Nausea and vomiting was moderate and well controlled with antiemetics. No complete or partial responses were observed, with a median time to progression of 58 days and a median survival of 227 + days for the entire group. Based on these results we do not recommend I.V. 6-thioguanine for the treatment of this disease.

Original language	English (US)
Pages (from-to)	89-91
Number of pages	3
Journal	Investigational New Drugs
Volume	10
Issue number	2
DOIs	https://doi.org/10.1007/BF00873122
State	Published - Jun 1992

All Science Journal Classification (ASJC) codes

Oncology
Pharmacology
Pharmacology (medical)

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10.1007/BF00873122

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title = "Phase II trial of 5 day continuous intravenous infusion of 6-thioguanine in patients with recurrent and metastatic squamous cell carcinoma of the head and neck",

abstract = "Fifteen patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck received a 5 day continuous I.V. infusion of 6-thioguanine repeated every five weeks. Dose limiting toxicity was primarily hematological with grade III/IV leucopenia and thrombocytopenia seen in seven patients. Nausea and vomiting was moderate and well controlled with antiemetics. No complete or partial responses were observed, with a median time to progression of 58 days and a median survival of 227 + days for the entire group. Based on these results we do not recommend I.V. 6-thioguanine for the treatment of this disease.",

author = "Flavio Kruter and Mario Eisenberger and Victoria Sinibaldi and Christine Engstrom and Maria Jacobs and Jeffrey Abrams and Chandra Belani and William Gray and Steven Krasnow",

year = "1992",

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T1 - Phase II trial of 5 day continuous intravenous infusion of 6-thioguanine in patients with recurrent and metastatic squamous cell carcinoma of the head and neck

AU - Kruter, Flavio

AU - Eisenberger, Mario

AU - Sinibaldi, Victoria

AU - Engstrom, Christine

AU - Jacobs, Maria

AU - Abrams, Jeffrey

AU - Belani, Chandra

AU - Gray, William

AU - Krasnow, Steven

PY - 1992/6

Y1 - 1992/6

N2 - Fifteen patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck received a 5 day continuous I.V. infusion of 6-thioguanine repeated every five weeks. Dose limiting toxicity was primarily hematological with grade III/IV leucopenia and thrombocytopenia seen in seven patients. Nausea and vomiting was moderate and well controlled with antiemetics. No complete or partial responses were observed, with a median time to progression of 58 days and a median survival of 227 + days for the entire group. Based on these results we do not recommend I.V. 6-thioguanine for the treatment of this disease.

AB - Fifteen patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck received a 5 day continuous I.V. infusion of 6-thioguanine repeated every five weeks. Dose limiting toxicity was primarily hematological with grade III/IV leucopenia and thrombocytopenia seen in seven patients. Nausea and vomiting was moderate and well controlled with antiemetics. No complete or partial responses were observed, with a median time to progression of 58 days and a median survival of 227 + days for the entire group. Based on these results we do not recommend I.V. 6-thioguanine for the treatment of this disease.

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Phase II trial of 5 day continuous intravenous infusion of 6-thioguanine in patients with recurrent and metastatic squamous cell carcinoma of the head and neck

Abstract

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