Phenytoin decreases the blood concentrations of sirolimus in a liver transplant recipient: A case report

Jonathan A. Fridell; Ashok Kumar B. Jain; Kusum Patel; Mohamed Virji; K. N. Rao; John J. Fung; Raman Venkataramanan

doi:10.1097/00007691-200302000-00019

Phenytoin decreases the blood concentrations of sirolimus in a liver transplant recipient: A case report

Jonathan A. Fridell
, Ashok Kumar B. Jain
, Kusum Patel
, Mohamed Virji
, K. N. Rao
, John J. Fung
, Raman Venkataramanan

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

This report documents that coadministration of phenytoin leads to decreased blood concentrations and area under the blood concentration-time curve of sirolimus in a liver transplant patient. It is essential to monitor the blood concentrations of sirolimus and adjust the sirolimus dosage when phenytoin administration begins or ends.

Original language	English (US)
Pages (from-to)	117-119
Number of pages	3
Journal	Therapeutic Drug Monitoring
Volume	25
Issue number	1
DOIs	https://doi.org/10.1097/00007691-200302000-00019
State	Published - Feb 2003

All Science Journal Classification (ASJC) codes

General Medicine

Access to Document

10.1097/00007691-200302000-00019

Cite this

@article{6bf26230eeee4a8b9a08a017acfba5ef,

title = "Phenytoin decreases the blood concentrations of sirolimus in a liver transplant recipient: A case report",

abstract = "This report documents that coadministration of phenytoin leads to decreased blood concentrations and area under the blood concentration-time curve of sirolimus in a liver transplant patient. It is essential to monitor the blood concentrations of sirolimus and adjust the sirolimus dosage when phenytoin administration begins or ends.",

author = "Fridell, \{Jonathan A.\} and Jain, \{Ashok Kumar B.\} and Kusum Patel and Mohamed Virji and Rao, \{K. N.\} and Fung, \{John J.\} and Raman Venkataramanan",

year = "2003",

month = feb,

doi = "10.1097/00007691-200302000-00019",

language = "English (US)",

volume = "25",

pages = "117--119",

journal = "Therapeutic Drug Monitoring",

issn = "0163-4356",

publisher = "Lippincott Williams and Wilkins",

number = "1",

}

TY - JOUR

T1 - Phenytoin decreases the blood concentrations of sirolimus in a liver transplant recipient

T2 - A case report

AU - Fridell, Jonathan A.

AU - Jain, Ashok Kumar B.

AU - Patel, Kusum

AU - Virji, Mohamed

AU - Rao, K. N.

AU - Fung, John J.

AU - Venkataramanan, Raman

PY - 2003/2

Y1 - 2003/2

N2 - This report documents that coadministration of phenytoin leads to decreased blood concentrations and area under the blood concentration-time curve of sirolimus in a liver transplant patient. It is essential to monitor the blood concentrations of sirolimus and adjust the sirolimus dosage when phenytoin administration begins or ends.

AB - This report documents that coadministration of phenytoin leads to decreased blood concentrations and area under the blood concentration-time curve of sirolimus in a liver transplant patient. It is essential to monitor the blood concentrations of sirolimus and adjust the sirolimus dosage when phenytoin administration begins or ends.

UR - https://www.scopus.com/pages/publications/0037304694

UR - https://www.scopus.com/pages/publications/0037304694#tab=citedBy

U2 - 10.1097/00007691-200302000-00019

DO - 10.1097/00007691-200302000-00019

M3 - Article

C2 - 12548156

AN - SCOPUS:0037304694

SN - 0163-4356

VL - 25

SP - 117

EP - 119

JO - Therapeutic Drug Monitoring

JF - Therapeutic Drug Monitoring

IS - 1

ER -

Phenytoin decreases the blood concentrations of sirolimus in a liver transplant recipient: A case report

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this