Abstract
We report a highly efficient and chemoselective Minisci-type alkylation reaction of N-heteroarenes with alkanes under the reagent control of a hypervalent iodine oxidant PFBI-OH. In addition to the high reactivity, PFBI-OH demonstrated a high steric sensitivity for H abstraction of alkanes. This reaction is selective for more sterically accessible secondary C-H bonds over weaker tertiary C-H bonds. High selectivity toward penultimate methylene groups was observed for a wide range of acyclic alkanes.
Original language | English (US) |
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Pages (from-to) | 11847-11853 |
Number of pages | 7 |
Journal | ACS Catalysis |
Volume | 8 |
Issue number | 12 |
DOIs | |
State | Published - Dec 7 2018 |
All Science Journal Classification (ASJC) codes
- Catalysis
- Chemistry(all)