Phylogenetic analysis of the mammalian Hoxc8 non-coding region

Chang Bae Kim; Cooduvalli S. Shashikant; Kenta Sumiyama; Wayne C.H. Wang; Chris T. Amemiya; Frank H. Ruddle

doi:10.1023/A:1022635623260

Phylogenetic analysis of the mammalian Hoxc8 non-coding region

Chang Bae Kim, Cooduvalli S. Shashikant, Kenta Sumiyama, Wayne C.H. Wang, Chris T. Amemiya, Frank H. Ruddle

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The non-coding intergenic regions of Hox genes are remarkably conserved among mammals. To determine the usefulness of this sequence for phylogenetic comparisons, we sequenced an 800-bp fragment of the Hoxc9-Hoxc8 intergenic region from several species belonging to different mammalian clades. Results obtained from the phylogenetic analysis are congruent with currently accepted mammalian phylogeny. Additionally, we found a TC mini satellite repeat polymorphism unique to felines. This polymorphism may serve as a useful marker to differentiate between mammalian species or as a genetic marker in feline matings. This study demonstrates usefulness of a comparative approach employing non-coding regions of Hox gene complexes.

Original language	English (US)
Pages (from-to)	195-199
Number of pages	5
Journal	Journal of Structural and Functional Genomics
Volume	3
Issue number	1-4
DOIs	https://doi.org/10.1023/A:1022635623260
State	Published - 2003

All Science Journal Classification (ASJC) codes

Structural Biology
Biochemistry
Genetics

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@article{16707d9e84d747129ddde34be966ead9,

title = "Phylogenetic analysis of the mammalian Hoxc8 non-coding region",

abstract = "The non-coding intergenic regions of Hox genes are remarkably conserved among mammals. To determine the usefulness of this sequence for phylogenetic comparisons, we sequenced an 800-bp fragment of the Hoxc9-Hoxc8 intergenic region from several species belonging to different mammalian clades. Results obtained from the phylogenetic analysis are congruent with currently accepted mammalian phylogeny. Additionally, we found a TC mini satellite repeat polymorphism unique to felines. This polymorphism may serve as a useful marker to differentiate between mammalian species or as a genetic marker in feline matings. This study demonstrates usefulness of a comparative approach employing non-coding regions of Hox gene complexes.",

author = "Kim, {Chang Bae} and Shashikant, {Cooduvalli S.} and Kenta Sumiyama and Wang, {Wayne C.H.} and Amemiya, {Chris T.} and Ruddle, {Frank H.}",

note = "Funding Information: We thank Drs. S. O{\textquoteright}Brien and U. Arnason for sending genomic DNAs, and Christina Ledje and Chi-Hua Chiu for reading the manuscript. The study was supported by grants from the National Science Foundation (IBN–9630567 and IBN–9905408) and the National Institutes of Health (GM09966 and R24-RR14085) (to FHR and CTA, respectively) and faculty start-up funds for CSS.",

year = "2003",

doi = "10.1023/A:1022635623260",

language = "English (US)",

volume = "3",

pages = "195--199",

journal = "Journal of Structural and Functional Genomics",

issn = "1345-711X",

publisher = "Springer Netherlands",

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T1 - Phylogenetic analysis of the mammalian Hoxc8 non-coding region

AU - Kim, Chang Bae

AU - Shashikant, Cooduvalli S.

AU - Sumiyama, Kenta

AU - Wang, Wayne C.H.

AU - Amemiya, Chris T.

AU - Ruddle, Frank H.

N1 - Funding Information: We thank Drs. S. O’Brien and U. Arnason for sending genomic DNAs, and Christina Ledje and Chi-Hua Chiu for reading the manuscript. The study was supported by grants from the National Science Foundation (IBN–9630567 and IBN–9905408) and the National Institutes of Health (GM09966 and R24-RR14085) (to FHR and CTA, respectively) and faculty start-up funds for CSS.

PY - 2003

Y1 - 2003

N2 - The non-coding intergenic regions of Hox genes are remarkably conserved among mammals. To determine the usefulness of this sequence for phylogenetic comparisons, we sequenced an 800-bp fragment of the Hoxc9-Hoxc8 intergenic region from several species belonging to different mammalian clades. Results obtained from the phylogenetic analysis are congruent with currently accepted mammalian phylogeny. Additionally, we found a TC mini satellite repeat polymorphism unique to felines. This polymorphism may serve as a useful marker to differentiate between mammalian species or as a genetic marker in feline matings. This study demonstrates usefulness of a comparative approach employing non-coding regions of Hox gene complexes.

AB - The non-coding intergenic regions of Hox genes are remarkably conserved among mammals. To determine the usefulness of this sequence for phylogenetic comparisons, we sequenced an 800-bp fragment of the Hoxc9-Hoxc8 intergenic region from several species belonging to different mammalian clades. Results obtained from the phylogenetic analysis are congruent with currently accepted mammalian phylogeny. Additionally, we found a TC mini satellite repeat polymorphism unique to felines. This polymorphism may serve as a useful marker to differentiate between mammalian species or as a genetic marker in feline matings. This study demonstrates usefulness of a comparative approach employing non-coding regions of Hox gene complexes.

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JO - Journal of Structural and Functional Genomics

JF - Journal of Structural and Functional Genomics

IS - 1-4

ER -

Phylogenetic analysis of the mammalian Hoxc8 non-coding region

Abstract

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