Physical activity and lung cancer among non-smokers: A pilot molecular epidemiological study within EPIC

Andrew Rundle, John Richie, Karen Steindorf, Marco Peluso, Kim Overvad, Ole Raaschou-Nielsen, Francoise Clavel-Chapelon, Jacob P. Linseisen, Heiner Boeing, Antonia Trichopoulou, Domenico Palli, Vittorio Krogh, Rosario Tumino, Salvatore Panico, Hendrik B. Bueno-De-Mesquita, Petra H. Peeters, Eiliv Lund, Carlos A. Gonzalez, Carmen Martinez, Miren DorronsoroAurelio Barricarte, M. Jose Tormo, José R. Quiros, Antonio Agudo, Goran Berglund, Bengt Jarvholm, Sheila Bingham, Timothy J. Key, Emmanuelle Gormally, Rodolfo Saracci, Rudolf Kaaks, Elio Riboli, Paolo Vineis

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


The association between physical activity, potential intermediate biomarkers and lung cancer risk was investigated in a study of 230 cases and 648 controls nested within the European Prospective Investigation of Cancer and Nutrition. Data on white blood cell aromatic-DNA adducts by 32P-post- labelling and glutathione (GSH) in red blood cells were available from a subset of cases and controls. Compared with the first quartile, the fourth quartile of recreational physical activity was associated with a lower lung cancer risk (odds ratio (OR) 0.56, 95% confidence interval (CI) 0.350.90), higher GSH levels (1.87 μmol GSH g-1 haemoglobin, p 0.04) but not with the presence of high levels of adducts (OR 1.05, 95% CI 0.382.86). Despite being associated with recreational physical activity, in these small-scale pilot analyses GSH levels were not associated with lung cancer risk (OR 0.95, 95% CI 0.841.07 per unit increase in GSH levels). Household and occupational activity was not associated with lung cancer risk or biomarker levels.

Original languageEnglish (US)
Pages (from-to)20-30
Number of pages11
Issue number1
StatePublished - Feb 2010

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis


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