TY - JOUR
T1 - Physical activity and lung cancer among non-smokers
T2 - A pilot molecular epidemiological study within EPIC
AU - Rundle, Andrew
AU - Richie, John
AU - Steindorf, Karen
AU - Peluso, Marco
AU - Overvad, Kim
AU - Raaschou-Nielsen, Ole
AU - Clavel-Chapelon, Francoise
AU - Linseisen, Jacob P.
AU - Boeing, Heiner
AU - Trichopoulou, Antonia
AU - Palli, Domenico
AU - Krogh, Vittorio
AU - Tumino, Rosario
AU - Panico, Salvatore
AU - Bueno-De-Mesquita, Hendrik B.
AU - Peeters, Petra H.
AU - Lund, Eiliv
AU - Gonzalez, Carlos A.
AU - Martinez, Carmen
AU - Dorronsoro, Miren
AU - Barricarte, Aurelio
AU - Tormo, M. Jose
AU - Quiros, José R.
AU - Agudo, Antonio
AU - Berglund, Goran
AU - Jarvholm, Bengt
AU - Bingham, Sheila
AU - Key, Timothy J.
AU - Gormally, Emmanuelle
AU - Saracci, Rodolfo
AU - Kaaks, Rudolf
AU - Riboli, Elio
AU - Vineis, Paolo
N1 - Funding Information:
Genetic Susceptibility to Air Pollution and Environmental Tobacco Smoking is a program of the European Community (QL4-1999-000927) Support was provided to Dr. Rundle by a Career Development Award from the National Cancer Center (KO7-CA92348-01A1).
PY - 2010/2
Y1 - 2010/2
N2 - The association between physical activity, potential intermediate biomarkers and lung cancer risk was investigated in a study of 230 cases and 648 controls nested within the European Prospective Investigation of Cancer and Nutrition. Data on white blood cell aromatic-DNA adducts by 32P-post- labelling and glutathione (GSH) in red blood cells were available from a subset of cases and controls. Compared with the first quartile, the fourth quartile of recreational physical activity was associated with a lower lung cancer risk (odds ratio (OR) 0.56, 95% confidence interval (CI) 0.350.90), higher GSH levels (1.87 μmol GSH g-1 haemoglobin, p 0.04) but not with the presence of high levels of adducts (OR 1.05, 95% CI 0.382.86). Despite being associated with recreational physical activity, in these small-scale pilot analyses GSH levels were not associated with lung cancer risk (OR 0.95, 95% CI 0.841.07 per unit increase in GSH levels). Household and occupational activity was not associated with lung cancer risk or biomarker levels.
AB - The association between physical activity, potential intermediate biomarkers and lung cancer risk was investigated in a study of 230 cases and 648 controls nested within the European Prospective Investigation of Cancer and Nutrition. Data on white blood cell aromatic-DNA adducts by 32P-post- labelling and glutathione (GSH) in red blood cells were available from a subset of cases and controls. Compared with the first quartile, the fourth quartile of recreational physical activity was associated with a lower lung cancer risk (odds ratio (OR) 0.56, 95% confidence interval (CI) 0.350.90), higher GSH levels (1.87 μmol GSH g-1 haemoglobin, p 0.04) but not with the presence of high levels of adducts (OR 1.05, 95% CI 0.382.86). Despite being associated with recreational physical activity, in these small-scale pilot analyses GSH levels were not associated with lung cancer risk (OR 0.95, 95% CI 0.841.07 per unit increase in GSH levels). Household and occupational activity was not associated with lung cancer risk or biomarker levels.
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U2 - 10.3109/13547500903186452
DO - 10.3109/13547500903186452
M3 - Article
C2 - 20050820
AN - SCOPUS:75749126106
SN - 1354-750X
VL - 15
SP - 20
EP - 30
JO - Biomarkers
JF - Biomarkers
IS - 1
ER -
