TY - JOUR
T1 - Physical activity and prodromal features of Parkinson disease
AU - Hughes, Katherine C.
AU - Gao, Xiang
AU - Molsberry, Samantha
AU - Valeri, Linda
AU - Schwarzschild, Michael A.
AU - Ascherio, Alberto
N1 - Publisher Copyright:
© 2019 American Academy of Neurology.
PY - 2019/12/3
Y1 - 2019/12/3
N2 - ObjectiveTo investigate the relationship between physical activity and prodromal features of Parkinson disease that often precede the clinical diagnosis.MethodsIncluded are participants in 2 well-established cohorts: the Nurses' Health Study and the Health Professionals Follow-up Study. Physical activity was assessed using validated questionnaires at baseline (1986) and every 2 years until 2008. Prodromal features (e.g., constipation, hyposmia, and probable REM sleep behavior disorder [pRBD]) were assessed in 2012-2014.ResultsThe multivariable-adjusted odds ratio (OR) for having ≥3 prodromal features vs none comparing the highest to the lowest quintile were 0.65 (95% confidence interval [CI] 0.53-0.79; ptrend = 0.0006) for baseline physical activity and 0.52 (95% CI 0.35-0.76; ptrend = 0.009) for cumulative average physical activity. Considering each feature independently, baseline physical activity was associated with lower odds of constipation (OR 0.78, 95% CI 0.73-0.83; ptrend < 0.0001), excessive daytime sleepiness (OR 0.72, 95% CI 0.60-0.86; ptrend = 0.002), depressive symptoms (OR 0.82, 95% CI 0.69-0.97; ptrend = 0.13), and bodily pain (OR 0.81, 95% CI 0.68-0.96; ptrend = 0.03). Similar or stronger associations were observed for cumulative average physical activity, which, in addition, was associated with pRBD (OR 0.85, 95% CI 0.77-0.95; ptrend = 0.02). In contrast, neither hyposmia nor impaired color vision was associated with physical activity. Early life physical activity was associated with constipation and, in men only, with the co-occurrence of ≥3 features.ConclusionsThe reduced prevalence of prodromal features associated with Parkinson disease in older individuals who were more physically active in midlife and beyond is consistent with the hypothesis that high levels of physical activity may reduce risk of Parkinson disease.
AB - ObjectiveTo investigate the relationship between physical activity and prodromal features of Parkinson disease that often precede the clinical diagnosis.MethodsIncluded are participants in 2 well-established cohorts: the Nurses' Health Study and the Health Professionals Follow-up Study. Physical activity was assessed using validated questionnaires at baseline (1986) and every 2 years until 2008. Prodromal features (e.g., constipation, hyposmia, and probable REM sleep behavior disorder [pRBD]) were assessed in 2012-2014.ResultsThe multivariable-adjusted odds ratio (OR) for having ≥3 prodromal features vs none comparing the highest to the lowest quintile were 0.65 (95% confidence interval [CI] 0.53-0.79; ptrend = 0.0006) for baseline physical activity and 0.52 (95% CI 0.35-0.76; ptrend = 0.009) for cumulative average physical activity. Considering each feature independently, baseline physical activity was associated with lower odds of constipation (OR 0.78, 95% CI 0.73-0.83; ptrend < 0.0001), excessive daytime sleepiness (OR 0.72, 95% CI 0.60-0.86; ptrend = 0.002), depressive symptoms (OR 0.82, 95% CI 0.69-0.97; ptrend = 0.13), and bodily pain (OR 0.81, 95% CI 0.68-0.96; ptrend = 0.03). Similar or stronger associations were observed for cumulative average physical activity, which, in addition, was associated with pRBD (OR 0.85, 95% CI 0.77-0.95; ptrend = 0.02). In contrast, neither hyposmia nor impaired color vision was associated with physical activity. Early life physical activity was associated with constipation and, in men only, with the co-occurrence of ≥3 features.ConclusionsThe reduced prevalence of prodromal features associated with Parkinson disease in older individuals who were more physically active in midlife and beyond is consistent with the hypothesis that high levels of physical activity may reduce risk of Parkinson disease.
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U2 - 10.1212/WNL.0000000000008567
DO - 10.1212/WNL.0000000000008567
M3 - Article
C2 - 31719136
AN - SCOPUS:85076125061
SN - 0028-3878
VL - 93
SP - E2157-E2169
JO - Neurology
JF - Neurology
IS - 23
ER -