TY - JOUR
T1 - Physical activity and prostate cancer in the Alpha-Tocopherol, Beta-Carotene (ATBC) Cancer Prevention Study (Finland)
AU - Hartman, Terryl J.
AU - Albanes, Demetrius
AU - Rautalahti, Matti
AU - Tangrea, Joseph A.
AU - Virtamo, Jarmo
AU - Stolzenberg, Rachael
AU - Taylor, Philip R.
N1 - Funding Information:
Drs Hartman, Albanes, Tangrea, and Taylor and Ms Stolzenberg are with the Division of Clinical Sciences, National Cancer Institute, Bethesda, MD, USA. Drs Rautalahti and Virtamo are with the National Public Health Institute, Helsinki, Finland. Address correspondence to Dr Hartman, National Cancer Institute, Executive Plaza North, Suite 211, 6130 Executive Boulevard MSC 7326, Bethesda MD 20892-7326, USA. This work was supported by Public Health Service contract N01 CN 45165 from the US National Cancer Institute, National Institutes of Health, Department of Health and Human Services.
PY - 1998
Y1 - 1998
N2 - The association between physical activity and prostate cancer was evaluated in the trial-based cohort of the Alpha-Tocopherol, Beta-Carotene (ATBC) Cancer Prevention Study (n = 29,133). During up to nine years of follow-up, 317 men developed incident prostate cancer. The relationship between occupational, leisure, and combined activity and prostate cancer was assessed in multivariate Cox regression models that adjusted for intervention group, benign prostatic hyperplasia, age, smoking, and urban residence. Compared with sedentary workers, relative risks (RR) and 95 percent confidence intervals (CI) for occupational walkers, walker/lifters, and heavy laborers were 0.6 (CI = 0.4-1.0), 0.8 (CI = 0.5-1.3), and 1.2 (CI = 0.7-2.0), respectively. Among working men, leisure activity (active cf sedentary) was associated inversely with risk (RR = 0.7, CI = 0.5-0.9). This inverse association for leisure activity was observed, with the exception of heavy laborers, for all occupational activity levels, and was strongest among walkers compared with men sedentary at work and leisure, and to a lesser degree among walker/lifters. These results are consistent with a protective effect of physical activity on prostate cancer.
AB - The association between physical activity and prostate cancer was evaluated in the trial-based cohort of the Alpha-Tocopherol, Beta-Carotene (ATBC) Cancer Prevention Study (n = 29,133). During up to nine years of follow-up, 317 men developed incident prostate cancer. The relationship between occupational, leisure, and combined activity and prostate cancer was assessed in multivariate Cox regression models that adjusted for intervention group, benign prostatic hyperplasia, age, smoking, and urban residence. Compared with sedentary workers, relative risks (RR) and 95 percent confidence intervals (CI) for occupational walkers, walker/lifters, and heavy laborers were 0.6 (CI = 0.4-1.0), 0.8 (CI = 0.5-1.3), and 1.2 (CI = 0.7-2.0), respectively. Among working men, leisure activity (active cf sedentary) was associated inversely with risk (RR = 0.7, CI = 0.5-0.9). This inverse association for leisure activity was observed, with the exception of heavy laborers, for all occupational activity levels, and was strongest among walkers compared with men sedentary at work and leisure, and to a lesser degree among walker/lifters. These results are consistent with a protective effect of physical activity on prostate cancer.
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U2 - 10.1023/A:1008889001519
DO - 10.1023/A:1008889001519
M3 - Article
C2 - 9486459
AN - SCOPUS:0031974466
SN - 0957-5243
VL - 9
SP - 11
EP - 18
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 1
ER -