Physical activity and prostate cancer in the Alpha-Tocopherol, Beta-Carotene (ATBC) Cancer Prevention Study (Finland)

Terryl J. Hartman, Demetrius Albanes, Matti Rautalahti, Joseph A. Tangrea, Jarmo Virtamo, Rachael Stolzenberg, Philip R. Taylor

Research output: Contribution to journalArticlepeer-review

64 Scopus citations

Abstract

The association between physical activity and prostate cancer was evaluated in the trial-based cohort of the Alpha-Tocopherol, Beta-Carotene (ATBC) Cancer Prevention Study (n = 29,133). During up to nine years of follow-up, 317 men developed incident prostate cancer. The relationship between occupational, leisure, and combined activity and prostate cancer was assessed in multivariate Cox regression models that adjusted for intervention group, benign prostatic hyperplasia, age, smoking, and urban residence. Compared with sedentary workers, relative risks (RR) and 95 percent confidence intervals (CI) for occupational walkers, walker/lifters, and heavy laborers were 0.6 (CI = 0.4-1.0), 0.8 (CI = 0.5-1.3), and 1.2 (CI = 0.7-2.0), respectively. Among working men, leisure activity (active cf sedentary) was associated inversely with risk (RR = 0.7, CI = 0.5-0.9). This inverse association for leisure activity was observed, with the exception of heavy laborers, for all occupational activity levels, and was strongest among walkers compared with men sedentary at work and leisure, and to a lesser degree among walker/lifters. These results are consistent with a protective effect of physical activity on prostate cancer.

Original languageEnglish (US)
Pages (from-to)11-18
Number of pages8
JournalCancer Causes and Control
Volume9
Issue number1
DOIs
StatePublished - 1998

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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