TY - JOUR
T1 - Physical activity is associated with behavioral and neural changes across the lifespan
AU - Vinodh Kumar, G.
AU - Lacey, Simon
AU - Sathian, K.
N1 - Publisher Copyright:
© 2023 Elsevier B.V.
PY - 2023/7/27
Y1 - 2023/7/27
N2 - Physical activity is known to positively impact brain structure and function, but its effects on resting-state functional connectivity (rsFC) and its relationship with complex tasks as a function of age remain unclear. Here, we address these issues in a large population-based sample (N = 540) from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) repository. We relate levels of physical activity to rsFC patterns in magnetoencephalographic (MEG) and functional magnetic resonance imaging (fMRI) data, and to measures of executive function and visuomotor adaptation, across the lifespan. We show that higher self-reported daily physical activity is associated with lower alpha-band (8–12 Hz) global coherence, indicating weaker synchrony of neural oscillations in this band. Physical activity affected between-network connectivity of resting-state functional networks, although its effects on individual networks did not survive correction for multiple comparisons. Furthermore, our results indicate that greater engagement in day-to-day physical activity is associated with better visuomotor adaptation, across the lifespan. Overall, our findings indicate that rsFC metrics indexed by MEG and fMRI are sensitive indicators of the brain's response to physical activity, and that a physically active lifestyle affects multiple aspects of neural function across the lifespan.
AB - Physical activity is known to positively impact brain structure and function, but its effects on resting-state functional connectivity (rsFC) and its relationship with complex tasks as a function of age remain unclear. Here, we address these issues in a large population-based sample (N = 540) from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) repository. We relate levels of physical activity to rsFC patterns in magnetoencephalographic (MEG) and functional magnetic resonance imaging (fMRI) data, and to measures of executive function and visuomotor adaptation, across the lifespan. We show that higher self-reported daily physical activity is associated with lower alpha-band (8–12 Hz) global coherence, indicating weaker synchrony of neural oscillations in this band. Physical activity affected between-network connectivity of resting-state functional networks, although its effects on individual networks did not survive correction for multiple comparisons. Furthermore, our results indicate that greater engagement in day-to-day physical activity is associated with better visuomotor adaptation, across the lifespan. Overall, our findings indicate that rsFC metrics indexed by MEG and fMRI are sensitive indicators of the brain's response to physical activity, and that a physically active lifestyle affects multiple aspects of neural function across the lifespan.
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U2 - 10.1016/j.neulet.2023.137355
DO - 10.1016/j.neulet.2023.137355
M3 - Article
C2 - 37391064
AN - SCOPUS:85163805878
SN - 0304-3940
VL - 810
JO - Neuroscience letters
JF - Neuroscience letters
M1 - 137355
ER -