Physiological derangement of the trauma patient

Henry Liu, Hong Yan, Seth Christian, Santiago Gomez, Frank Rosinia, Mingbing Chen, Juan Tan, Charles J. Fox, Alan David Kaye

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


This chapter provides a systemic review of trauma-related physiological changes with tremendous updated information. The first part of this chapter analyzed the general physiological changes according to the following categories: (1) hemorrhage-related changes: trauma-related vicious cycle of hemorrhage, resuscitation, and coagulopathy; mechanisms of acute trauma coagulopathy (excessive activation of coagulation, hyperfibrinolysis, hypothermia, acidosis, increased capillary permeability, and platelet dysfunction). (2) Stress-related changes (behavioral activation). (3) Pain-related changes (ventilation and mental status). (4) Inflammatory changes and sepsis. (5) Metabolic changes. The second part of the chapter discussed three system-specific physiological changes after trauma: head trauma, chest and cardiac trauma, and trauma to abdominal and digestive system.

Original languageEnglish (US)
Title of host publicationAnesthesia for Trauma
Subtitle of host publicationNew Evidence and New Challenges
PublisherSpringer New York
Number of pages21
ISBN (Electronic)9781493909094
ISBN (Print)1493909088, 9781493909087
StatePublished - Mar 1 2014

All Science Journal Classification (ASJC) codes

  • General Medicine


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