TY - JOUR
T1 - Physiology in medicine
T2 - Peripheral arterial disease
AU - Muller, Matthew D.
AU - Reed, Amy B.
AU - Leuenberger, Urs A.
AU - Sinoway, Lawrence I.
PY - 2013/11/1
Y1 - 2013/11/1
N2 - Peripheral arterial disease (PAD) is an atherosclerotic condition that can provoke symptoms of leg pain ("intermittent claudication") during exercise. Because PAD is often observed with comorbid conditions such hypertension, dyslipidemia, diabetes, cigarette smoking, and/or physical inactivity, the pathophysiology of PAD is certainly complex and involves multiple organ systems. Patients with PAD are at high risk for myocardial infarction, stroke, and all-cause mortality. For this reason, a better physiological understanding of the pathogenesis and treatment options for PAD patients is necessary and forms the basis of this Physiology in Medicine review.
AB - Peripheral arterial disease (PAD) is an atherosclerotic condition that can provoke symptoms of leg pain ("intermittent claudication") during exercise. Because PAD is often observed with comorbid conditions such hypertension, dyslipidemia, diabetes, cigarette smoking, and/or physical inactivity, the pathophysiology of PAD is certainly complex and involves multiple organ systems. Patients with PAD are at high risk for myocardial infarction, stroke, and all-cause mortality. For this reason, a better physiological understanding of the pathogenesis and treatment options for PAD patients is necessary and forms the basis of this Physiology in Medicine review.
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U2 - 10.1152/japplphysiol.00885.2013
DO - 10.1152/japplphysiol.00885.2013
M3 - Review article
C2 - 23970534
AN - SCOPUS:84887126479
SN - 8750-7587
VL - 115
SP - 1219
EP - 1226
JO - Journal of applied physiology
JF - Journal of applied physiology
IS - 9
ER -