Physiology of tmRNA: what gets tagged and why?

Kenneth C. Keiler

doi:10.1016/j.mib.2007.03.014

Physiology of tmRNA: what gets tagged and why?

Kenneth C. Keiler

Research output: Contribution to journal › Review article › peer-review

42 Scopus citations

Abstract

Transfer-messenger RNA (tmRNA) enters stalled translational complexes and, with small protein B (SmpB), mediates peptide tagging of the nascent protein and release of the stalled ribosome. Recent studies clarify how the tmRNA system is targeted to ribosomes and suggest that tmRNA-tagging is used for both quality control and specific regulation of cellular physiology.

Original language	English (US)
Pages (from-to)	169-175
Number of pages	7
Journal	Current Opinion in Microbiology
Volume	10
Issue number	2
DOIs	https://doi.org/10.1016/j.mib.2007.03.014
State	Published - Apr 2007

All Science Journal Classification (ASJC) codes

Microbiology
Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.mib.2007.03.014

Cite this

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title = "Physiology of tmRNA: what gets tagged and why?",

abstract = "Transfer-messenger RNA (tmRNA) enters stalled translational complexes and, with small protein B (SmpB), mediates peptide tagging of the nascent protein and release of the stalled ribosome. Recent studies clarify how the tmRNA system is targeted to ribosomes and suggest that tmRNA-tagging is used for both quality control and specific regulation of cellular physiology.",

author = "Keiler, {Kenneth C.}",

note = "Funding Information: Sincere thanks to Sarah Ades, Wali Karzai, Bob Sauer, Sean Moore and Chris Hayes for helpful discussions. Supported by National Institutes of Health Grant GM068720. ",

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AU - Keiler, Kenneth C.

N1 - Funding Information: Sincere thanks to Sarah Ades, Wali Karzai, Bob Sauer, Sean Moore and Chris Hayes for helpful discussions. Supported by National Institutes of Health Grant GM068720.

PY - 2007/4

Y1 - 2007/4

N2 - Transfer-messenger RNA (tmRNA) enters stalled translational complexes and, with small protein B (SmpB), mediates peptide tagging of the nascent protein and release of the stalled ribosome. Recent studies clarify how the tmRNA system is targeted to ribosomes and suggest that tmRNA-tagging is used for both quality control and specific regulation of cellular physiology.

AB - Transfer-messenger RNA (tmRNA) enters stalled translational complexes and, with small protein B (SmpB), mediates peptide tagging of the nascent protein and release of the stalled ribosome. Recent studies clarify how the tmRNA system is targeted to ribosomes and suggest that tmRNA-tagging is used for both quality control and specific regulation of cellular physiology.

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Physiology of tmRNA: what gets tagged and why?

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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