Pituitary adenylate cyclase activating polypeptide enhances rapid eye movement sleep in rats

Jidong Fang; Linda Payne; James M. Krueger

doi:10.1016/0006-8993(95)00443-T

Pituitary adenylate cyclase activating polypeptide enhances rapid eye movement sleep in rats

Jidong Fang, Linda Payne, James M. Krueger

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Pituitary adenylate cyclase activating polypeptide (PACAP), a member of the vasoactive intestinal polypeptide family, was tested for its effects on sleep in adult male Sprague-Dawley rats. PACAP was injected via intracerebro-ventricular cannula at light or dark onset; sleep and brain temperature (Tbr) were recorded for 12 h after injection. Rapid eye movement sleep (REMS) was significantly enhanced by 30 pmol, but not 3 or 300 pmol PACAP injected at dark onset. Non-REMS was not influenced by 3, 30, or 300 pmol PACAP Sleep and Tbr were not influenced by 3 or 30 pmol PACAP injected at light onset.

Original language	English (US)
Pages (from-to)	23-28
Number of pages	6
Journal	Brain research
Volume	686
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(95)00443-T
State	Published - Jul 17 1995

All Science Journal Classification (ASJC) codes

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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@article{4129e8be21c645728dcbd336faf4603f,

title = "Pituitary adenylate cyclase activating polypeptide enhances rapid eye movement sleep in rats",

abstract = "Pituitary adenylate cyclase activating polypeptide (PACAP), a member of the vasoactive intestinal polypeptide family, was tested for its effects on sleep in adult male Sprague-Dawley rats. PACAP was injected via intracerebro-ventricular cannula at light or dark onset; sleep and brain temperature (Tbr) were recorded for 12 h after injection. Rapid eye movement sleep (REMS) was significantly enhanced by 30 pmol, but not 3 or 300 pmol PACAP injected at dark onset. Non-REMS was not influenced by 3, 30, or 300 pmol PACAP Sleep and Tbr were not influenced by 3 or 30 pmol PACAP injected at light onset.",

author = "Jidong Fang and Linda Payne and Krueger, {James M.}",

note = "Funding Information: This study is supported in part by grants from NIH -NS-27250, NS-25378, and NS-31453; and by the Office of Naval Research N00014-90-J-1069. We wish to thank Dr. Levente Kap~s for his helpful comments on the manuscript. We appreciate the advice from Dr. John Harris and Dr. Jim Y. Wan on the statistical analyses.",

year = "1995",

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doi = "10.1016/0006-8993(95)00443-T",

language = "English (US)",

volume = "686",

pages = "23--28",

journal = "Brain research",

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T1 - Pituitary adenylate cyclase activating polypeptide enhances rapid eye movement sleep in rats

AU - Fang, Jidong

AU - Payne, Linda

AU - Krueger, James M.

N1 - Funding Information: This study is supported in part by grants from NIH -NS-27250, NS-25378, and NS-31453; and by the Office of Naval Research N00014-90-J-1069. We wish to thank Dr. Levente Kap~s for his helpful comments on the manuscript. We appreciate the advice from Dr. John Harris and Dr. Jim Y. Wan on the statistical analyses.

PY - 1995/7/17

Y1 - 1995/7/17

N2 - Pituitary adenylate cyclase activating polypeptide (PACAP), a member of the vasoactive intestinal polypeptide family, was tested for its effects on sleep in adult male Sprague-Dawley rats. PACAP was injected via intracerebro-ventricular cannula at light or dark onset; sleep and brain temperature (Tbr) were recorded for 12 h after injection. Rapid eye movement sleep (REMS) was significantly enhanced by 30 pmol, but not 3 or 300 pmol PACAP injected at dark onset. Non-REMS was not influenced by 3, 30, or 300 pmol PACAP Sleep and Tbr were not influenced by 3 or 30 pmol PACAP injected at light onset.

AB - Pituitary adenylate cyclase activating polypeptide (PACAP), a member of the vasoactive intestinal polypeptide family, was tested for its effects on sleep in adult male Sprague-Dawley rats. PACAP was injected via intracerebro-ventricular cannula at light or dark onset; sleep and brain temperature (Tbr) were recorded for 12 h after injection. Rapid eye movement sleep (REMS) was significantly enhanced by 30 pmol, but not 3 or 300 pmol PACAP injected at dark onset. Non-REMS was not influenced by 3, 30, or 300 pmol PACAP Sleep and Tbr were not influenced by 3 or 30 pmol PACAP injected at light onset.

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JO - Brain research

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Pituitary adenylate cyclase activating polypeptide enhances rapid eye movement sleep in rats

Abstract

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