PKR and the ribosome compete for mRNA

Rebecca Toroney; Philip C. Bevilacqua

doi:10.1038/nchembio.262

PKR and the ribosome compete for mRNA

Rebecca Toroney, Philip C. Bevilacqua

Research output: Contribution to journal › Short survey › peer-review

5 Scopus citations

Abstract

The RNA-activated protein kinase PKR inhibits translation initiation by sensing long viral double-stranded RNA. A new report indicates that PKR is also activated by a cellular mRNA, but only when ribosomes are not initiating translation.

Original language	English (US)
Pages (from-to)	873-874
Number of pages	2
Journal	Nature Chemical Biology
Volume	5
Issue number	12
DOIs	https://doi.org/10.1038/nchembio.262
State	Published - Dec 2009

All Science Journal Classification (ASJC) codes

Molecular Biology
Cell Biology

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10.1038/nchembio.262

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title = "PKR and the ribosome compete for mRNA",

abstract = "The RNA-activated protein kinase PKR inhibits translation initiation by sensing long viral double-stranded RNA. A new report indicates that PKR is also activated by a cellular mRNA, but only when ribosomes are not initiating translation.",

author = "Rebecca Toroney and Bevilacqua, {Philip C.}",

year = "2009",

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doi = "10.1038/nchembio.262",

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AU - Toroney, Rebecca

AU - Bevilacqua, Philip C.

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JO - Nature Chemical Biology

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PKR and the ribosome compete for mRNA

Abstract

All Science Journal Classification (ASJC) codes

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