PKR and the ribosome compete for mRNA

Rebecca Toroney; Philip C. Bevilacqua

doi:10.1038/nchembio.262

PKR and the ribosome compete for mRNA

Rebecca Toroney
, Philip C. Bevilacqua

Research output: Contribution to journal › Short survey › peer-review

5 Scopus citations

Abstract

The RNA-activated protein kinase PKR inhibits translation initiation by sensing long viral double-stranded RNA. A new report indicates that PKR is also activated by a cellular mRNA, but only when ribosomes are not initiating translation.

Original language	English (US)
Pages (from-to)	873-874
Number of pages	2
Journal	Nature Chemical Biology
Volume	5
Issue number	12
DOIs	https://doi.org/10.1038/nchembio.262
State	Published - Dec 2009

All Science Journal Classification (ASJC) codes

Molecular Biology
Cell Biology

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10.1038/nchembio.262

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title = "PKR and the ribosome compete for mRNA",

abstract = "The RNA-activated protein kinase PKR inhibits translation initiation by sensing long viral double-stranded RNA. A new report indicates that PKR is also activated by a cellular mRNA, but only when ribosomes are not initiating translation.",

author = "Rebecca Toroney and Bevilacqua, \{Philip C.\}",

year = "2009",

month = dec,

doi = "10.1038/nchembio.262",

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journal = "Nature Chemical Biology",

issn = "1552-4450",

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T1 - PKR and the ribosome compete for mRNA

AU - Toroney, Rebecca

AU - Bevilacqua, Philip C.

PY - 2009/12

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AB - The RNA-activated protein kinase PKR inhibits translation initiation by sensing long viral double-stranded RNA. A new report indicates that PKR is also activated by a cellular mRNA, but only when ribosomes are not initiating translation.

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DO - 10.1038/nchembio.262

M3 - Short survey

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AN - SCOPUS:73349084632

SN - 1552-4450

VL - 5

SP - 873

EP - 874

JO - Nature Chemical Biology

JF - Nature Chemical Biology

IS - 12

ER -

PKR and the ribosome compete for mRNA

Abstract

All Science Journal Classification (ASJC) codes

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