Placental prostaglandin levels in pre-eclampsia

Laurence M. Demers; Steven G. Gabbe

doi:10.1016/0002-9378(76)90478-6

Placental prostaglandin levels in pre-eclampsia

Laurence M. Demers, Steven G. Gabbe

Department of Pathology and Laboratory Medicine

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Pre-eclampsia is characterized by uteroplacental ischemia. Prostaglandins can alter systemic blood pressure as well as regulate blood flow to the fetoplacental unit. In the present study, levels of prostaglandin E were significantly decreased in placental tissue from pre-eclamptic patients. Prostaglandin F, a potent vasoconstrictor, was markedly elevated. These observations indicate that altered placental metabolism of prostaglandins is an important factor in the pathophysiology of pre-eclampsia.

Original language	English (US)
Pages (from-to)	137-139
Number of pages	3
Journal	American journal of obstetrics and gynecology
Volume	126
Issue number	1
DOIs	https://doi.org/10.1016/0002-9378(76)90478-6
State	Published - Sep 1 1976

All Science Journal Classification (ASJC) codes

Obstetrics and Gynecology

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10.1016/0002-9378(76)90478-6

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abstract = "Pre-eclampsia is characterized by uteroplacental ischemia. Prostaglandins can alter systemic blood pressure as well as regulate blood flow to the fetoplacental unit. In the present study, levels of prostaglandin E were significantly decreased in placental tissue from pre-eclamptic patients. Prostaglandin F, a potent vasoconstrictor, was markedly elevated. These observations indicate that altered placental metabolism of prostaglandins is an important factor in the pathophysiology of pre-eclampsia.",

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AB - Pre-eclampsia is characterized by uteroplacental ischemia. Prostaglandins can alter systemic blood pressure as well as regulate blood flow to the fetoplacental unit. In the present study, levels of prostaglandin E were significantly decreased in placental tissue from pre-eclamptic patients. Prostaglandin F, a potent vasoconstrictor, was markedly elevated. These observations indicate that altered placental metabolism of prostaglandins is an important factor in the pathophysiology of pre-eclampsia.

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Placental prostaglandin levels in pre-eclampsia

Abstract

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