Placental prostaglandin levels in pre-eclampsia

Laurence M. Demers, Steven G. Gabbe

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


Pre-eclampsia is characterized by uteroplacental ischemia. Prostaglandins can alter systemic blood pressure as well as regulate blood flow to the fetoplacental unit. In the present study, levels of prostaglandin E were significantly decreased in placental tissue from pre-eclamptic patients. Prostaglandin F, a potent vasoconstrictor, was markedly elevated. These observations indicate that altered placental metabolism of prostaglandins is an important factor in the pathophysiology of pre-eclampsia.

Original languageEnglish (US)
Pages (from-to)137-139
Number of pages3
JournalAmerican journal of obstetrics and gynecology
Issue number1
StatePublished - Sep 1 1976

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology


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