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Plasma calcitonin activity in a patient with thyroid medullary carcinoma and her children with osteopetrosis

  • M. Verdy
  • , R. Beaulieu
  • , L. Demers
  • , W. C. Sturtridge
  • , P. Thomas
  • , M. Ashwini Kumar

Research output: Contribution to journalArticlepeer-review

Abstract

Plasma calcitonin was measured in a 38-yr-old female patient with metastatic carcinoma of the thyroid, 3 yr after total thyroidectomy. There was a diffuse increase in skeletal density as well as an elevation in plasma calcitonin concentration. This patient had 11 pregnancies with 9 live births. At least 4 of the 9 children are believed to have had osteopetrosis. Two of the 4 have died but plasma calcitonin activity was measured in the 2 surviving children and was not found to be elevated. A relationship between circulating calcitonin excess and osteopetrosis cannot be substantiated. A genetic relationship between medullary carcinoma and osteopetrosis deserves investigation.

Original languageEnglish (US)
Pages (from-to)216-221
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume32
Issue number2
DOIs
StatePublished - 1971

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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