Plasma coagulation response to surfaces with nanoscale chemical heterogeneity

Rachel Miller; Zhe Guo; Erwin A. Vogler; Christopher Siedlecki

doi:10.1016/j.biomaterials.2005.05.087

Plasma coagulation response to surfaces with nanoscale chemical heterogeneity

Rachel Miller, Zhe Guo, Erwin A. Vogler, Christopher Siedlecki

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

A mixed film bearing nanoscale domains of one chemical functionality surrounded by another chemical functionality is shown to prolong material-induced coagulation of whole human blood plasma. In comparison, surfaces with uniform silane chemistry or physical mixtures of control surfaces bearing two different, uniform silane chemistries are found to be much more efficient activators of plasma coagulation on a per-unit-area basis. Binary mixed films are deposited on glass substrates by the sequential adsorption of 0.0001% 3-aminopropyltriethoxysilane (APS) followed by 0.1% n- butyltrichlorosilane (BTS). Creation of APS islands in a sea of BTS is confirmed by atomic force microscopy in friction mode. Results suggest that some yet-to-be-determined interfacial phenomena, perhaps associated with protein adsorption near the interface, may be altered by this nanoscale spatially distributed chemical heterogeneity, causing a decrease in contact activation.

Original language	English (US)
Pages (from-to)	208-215
Number of pages	8
Journal	Biomaterials
Volume	27
Issue number	2
DOIs	https://doi.org/10.1016/j.biomaterials.2005.05.087
State	Published - Jan 2006

All Science Journal Classification (ASJC) codes

Biophysics
Bioengineering
Ceramics and Composites
Biomaterials
Mechanics of Materials

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10.1016/j.biomaterials.2005.05.087

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title = "Plasma coagulation response to surfaces with nanoscale chemical heterogeneity",

abstract = "A mixed film bearing nanoscale domains of one chemical functionality surrounded by another chemical functionality is shown to prolong material-induced coagulation of whole human blood plasma. In comparison, surfaces with uniform silane chemistry or physical mixtures of control surfaces bearing two different, uniform silane chemistries are found to be much more efficient activators of plasma coagulation on a per-unit-area basis. Binary mixed films are deposited on glass substrates by the sequential adsorption of 0.0001% 3-aminopropyltriethoxysilane (APS) followed by 0.1% n- butyltrichlorosilane (BTS). Creation of APS islands in a sea of BTS is confirmed by atomic force microscopy in friction mode. Results suggest that some yet-to-be-determined interfacial phenomena, perhaps associated with protein adsorption near the interface, may be altered by this nanoscale spatially distributed chemical heterogeneity, causing a decrease in contact activation.",

author = "Rachel Miller and Zhe Guo and Vogler, {Erwin A.} and Christopher Siedlecki",

note = "Funding Information: This work was supported by NIH Grant 1R01 HL69965-03 and by the PSU Tobacco Formula Funding Program 02-173. The authors would also like to thank the Materials Research Institute and The Pennsylvania State University Departments of Bioengineering, Materials Science & Engineering, and Surgery. Mr. Aashiish Agnihotri is acknowledged for his assistance with AFM imaging and MATLAB programming, and Ms. Rui Zhuo is recognized for her helpful discussions.",

year = "2006",

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doi = "10.1016/j.biomaterials.2005.05.087",

language = "English (US)",

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pages = "208--215",

journal = "Biomaterials",

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AU - Guo, Zhe

AU - Vogler, Erwin A.

AU - Siedlecki, Christopher

N1 - Funding Information: This work was supported by NIH Grant 1R01 HL69965-03 and by the PSU Tobacco Formula Funding Program 02-173. The authors would also like to thank the Materials Research Institute and The Pennsylvania State University Departments of Bioengineering, Materials Science & Engineering, and Surgery. Mr. Aashiish Agnihotri is acknowledged for his assistance with AFM imaging and MATLAB programming, and Ms. Rui Zhuo is recognized for her helpful discussions.

PY - 2006/1

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N2 - A mixed film bearing nanoscale domains of one chemical functionality surrounded by another chemical functionality is shown to prolong material-induced coagulation of whole human blood plasma. In comparison, surfaces with uniform silane chemistry or physical mixtures of control surfaces bearing two different, uniform silane chemistries are found to be much more efficient activators of plasma coagulation on a per-unit-area basis. Binary mixed films are deposited on glass substrates by the sequential adsorption of 0.0001% 3-aminopropyltriethoxysilane (APS) followed by 0.1% n- butyltrichlorosilane (BTS). Creation of APS islands in a sea of BTS is confirmed by atomic force microscopy in friction mode. Results suggest that some yet-to-be-determined interfacial phenomena, perhaps associated with protein adsorption near the interface, may be altered by this nanoscale spatially distributed chemical heterogeneity, causing a decrease in contact activation.

AB - A mixed film bearing nanoscale domains of one chemical functionality surrounded by another chemical functionality is shown to prolong material-induced coagulation of whole human blood plasma. In comparison, surfaces with uniform silane chemistry or physical mixtures of control surfaces bearing two different, uniform silane chemistries are found to be much more efficient activators of plasma coagulation on a per-unit-area basis. Binary mixed films are deposited on glass substrates by the sequential adsorption of 0.0001% 3-aminopropyltriethoxysilane (APS) followed by 0.1% n- butyltrichlorosilane (BTS). Creation of APS islands in a sea of BTS is confirmed by atomic force microscopy in friction mode. Results suggest that some yet-to-be-determined interfacial phenomena, perhaps associated with protein adsorption near the interface, may be altered by this nanoscale spatially distributed chemical heterogeneity, causing a decrease in contact activation.

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Plasma coagulation response to surfaces with nanoscale chemical heterogeneity

Abstract

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