TY - GEN
T1 - Plasma lithography for control of cell morphology and proliferation
AU - Junkin, Michael
AU - Zhang, Donna D.
AU - Wong, Pak Kin
PY - 2009
Y1 - 2009
N2 - We have utilized a plasma based patterning technique [1], that we have developed, to study the effects of micrometer and submicrometer scale surface functionalization on cell proliferation and morphology. We have applied this method to cellular patterning and examined the response of mammalian cells to patterns of hydrophobic and hydrophilic areas created directly on polystyrene substrates. We have observed that the residual plasma pattern can serve as a template for cell attachment and growth on patterns at line widths -22 Jμm and larger. At smaller sizes, cells do not align themselves with the pattern, but their growth is affected and is significantly less than on homogeneous hydrophilic polystyrene surfaces. This type of patterning could have several uses including tissue engineering, medical implants, or providing a means for studying the fundamental behavior of cell to surface and other interactions.
AB - We have utilized a plasma based patterning technique [1], that we have developed, to study the effects of micrometer and submicrometer scale surface functionalization on cell proliferation and morphology. We have applied this method to cellular patterning and examined the response of mammalian cells to patterns of hydrophobic and hydrophilic areas created directly on polystyrene substrates. We have observed that the residual plasma pattern can serve as a template for cell attachment and growth on patterns at line widths -22 Jμm and larger. At smaller sizes, cells do not align themselves with the pattern, but their growth is affected and is significantly less than on homogeneous hydrophilic polystyrene surfaces. This type of patterning could have several uses including tissue engineering, medical implants, or providing a means for studying the fundamental behavior of cell to surface and other interactions.
UR - http://www.scopus.com/inward/record.url?scp=70349873556&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70349873556&partnerID=8YFLogxK
U2 - 10.1109/NEMS.2009.5068703
DO - 10.1109/NEMS.2009.5068703
M3 - Conference contribution
AN - SCOPUS:70349873556
SN - 9781424446308
T3 - 4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2009
SP - 822
EP - 826
BT - 4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2009
T2 - 4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2009
Y2 - 5 January 2009 through 8 January 2009
ER -