TY - JOUR
T1 - Plasma netrin-1 is a diagnostic biomarker of human cancers
AU - Ramesh, Ganesan
AU - Berg, Arthur
AU - Jayakumar, Calpurnia
N1 - Funding Information:
This work was supported by grants to Ganesan Ramesh from American Society of Nephrology (Carl S. Gottschalk Research Scholar Grant) and R01 grant (1R01DK083379 -01A2) from NIH-NIDDK. The authors have no financial conflicts of interest. The authors have no conflict of interest.
PY - 2011/3
Y1 - 2011/3
N2 - Context: The axon guidance cues netrin-1 is a secreted protein overexpressed in many different cancer tissues. Objectives:To determine whether plasma netrin-1 can be used as a diagnostic biomarker of human cancer. Materials and Methods:A total of 300 cancer plasma samples from breast, renal, prostate, liver, meningioma, pituitary adenoma, glioblastoma, lung, pancreatic and colon cancer patients were compared against 138 control plasma samples. Netrin-1 levels were quantified by ELISA and immunohistochemistry. Results:Plasma netrin-1 levels were significantly increased in breast, renal, prostate, liver, meningioma, pituitary adenoma, and glioblastoma cancers as compared to control samples. Discussion and Conclusion:Our results suggest that plasma netrin-1 can be used as a diagnostic biomarker for many human cancers.
AB - Context: The axon guidance cues netrin-1 is a secreted protein overexpressed in many different cancer tissues. Objectives:To determine whether plasma netrin-1 can be used as a diagnostic biomarker of human cancer. Materials and Methods:A total of 300 cancer plasma samples from breast, renal, prostate, liver, meningioma, pituitary adenoma, glioblastoma, lung, pancreatic and colon cancer patients were compared against 138 control plasma samples. Netrin-1 levels were quantified by ELISA and immunohistochemistry. Results:Plasma netrin-1 levels were significantly increased in breast, renal, prostate, liver, meningioma, pituitary adenoma, and glioblastoma cancers as compared to control samples. Discussion and Conclusion:Our results suggest that plasma netrin-1 can be used as a diagnostic biomarker for many human cancers.
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U2 - 10.3109/1354750X.2010.541564
DO - 10.3109/1354750X.2010.541564
M3 - Article
C2 - 21303223
AN - SCOPUS:79951858900
SN - 1354-750X
VL - 16
SP - 172
EP - 180
JO - Biomarkers
JF - Biomarkers
IS - 2
ER -
