Abstract
Context: The axon guidance cues netrin-1 is a secreted protein overexpressed in many different cancer tissues. Objectives:To determine whether plasma netrin-1 can be used as a diagnostic biomarker of human cancer. Materials and Methods:A total of 300 cancer plasma samples from breast, renal, prostate, liver, meningioma, pituitary adenoma, glioblastoma, lung, pancreatic and colon cancer patients were compared against 138 control plasma samples. Netrin-1 levels were quantified by ELISA and immunohistochemistry. Results:Plasma netrin-1 levels were significantly increased in breast, renal, prostate, liver, meningioma, pituitary adenoma, and glioblastoma cancers as compared to control samples. Discussion and Conclusion:Our results suggest that plasma netrin-1 can be used as a diagnostic biomarker for many human cancers.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 172-180 |
| Number of pages | 9 |
| Journal | Biomarkers |
| Volume | 16 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 2011 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
All Science Journal Classification (ASJC) codes
- Biochemistry
- Clinical Biochemistry
- Health, Toxicology and Mutagenesis
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