Plasma prostaglandins in hypercalcemic patients with neoplastic disease

Laurence Demers; J. C. Allegra; Harold Harvey; Allan Lipton; J. R. Luderer; R. Mortel; D. E. Brenner

doi:10.1002/1097-0142(197704)39:4<1559::AID-CNCR2820390430>3.0.CO;2-3

Plasma prostaglandins in hypercalcemic patients with neoplastic disease

Laurence Demers, J. C. Allegra, Harold Harvey, Allan Lipton, J. R. Luderer, R. Mortel, D. E. Brenner

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Abstract

Peripheral plasma prostaglandin E (PGE) determinations were performed on a series of 79 patients with solid tumor neoplasms and correlated with their serum calcium levels. Fourteen patients were hypercalcemic and 11 of these had significant elevations in circulating plasma PGE. Ten of the hypercalcemic group had extensive metastases to bone. These findings support the recently developed hypothesis that prostaglandins are causally related to the genesis of hypercalcemia in malignancy.

Original language	English (US)
Pages (from-to)	1559-1562
Number of pages	4
Journal	Cancer
Volume	39
Issue number	4
DOIs	https://doi.org/10.1002/1097-0142(197704)39:4<1559::AID-CNCR2820390430>3.0.CO;2-3
State	Published - Apr 1977

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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10.1002/1097-0142(197704)39:4<1559::AID-CNCR2820390430>3.0.CO;2-3

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author = "Laurence Demers and Allegra, {J. C.} and Harold Harvey and Allan Lipton and Luderer, {J. R.} and R. Mortel and Brenner, {D. E.}",

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T1 - Plasma prostaglandins in hypercalcemic patients with neoplastic disease

AU - Demers, Laurence

AU - Allegra, J. C.

AU - Harvey, Harold

AU - Lipton, Allan

AU - Luderer, J. R.

AU - Mortel, R.

AU - Brenner, D. E.

PY - 1977/4

Y1 - 1977/4

N2 - Peripheral plasma prostaglandin E (PGE) determinations were performed on a series of 79 patients with solid tumor neoplasms and correlated with their serum calcium levels. Fourteen patients were hypercalcemic and 11 of these had significant elevations in circulating plasma PGE. Ten of the hypercalcemic group had extensive metastases to bone. These findings support the recently developed hypothesis that prostaglandins are causally related to the genesis of hypercalcemia in malignancy.

AB - Peripheral plasma prostaglandin E (PGE) determinations were performed on a series of 79 patients with solid tumor neoplasms and correlated with their serum calcium levels. Fourteen patients were hypercalcemic and 11 of these had significant elevations in circulating plasma PGE. Ten of the hypercalcemic group had extensive metastases to bone. These findings support the recently developed hypothesis that prostaglandins are causally related to the genesis of hypercalcemia in malignancy.

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ER -

Plasma prostaglandins in hypercalcemic patients with neoplastic disease

Abstract

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