Plasmodium Parasites Viewed through Proteomics

Kristian E. Swearingen, Scott E. Lindner

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


Early sequencing efforts that produced the genomes of several species of malaria parasites (Plasmodium genus) propelled transcriptomic and proteomic efforts. In this review, we focus upon some of the exciting proteomic advances from studies of Plasmodium parasites over approximately the past decade. With improvements to both instrumentation and data-processing capabilities, long-standing questions about the forms and functions of these important pathogens are rapidly being answered. In particular, global and subcellular proteomics, quantitative proteomics, and the detection of post-translational modifications have all revealed important features of the parasite's regulatory mechanisms. Finally, we provide our perspectives on future applications of proteomics to Plasmodium research, as well as suggestions for further improvement through standardization of data deposition, analysis, and accessibility.

Original languageEnglish (US)
Pages (from-to)945-960
Number of pages16
JournalTrends in Parasitology
Issue number11
StatePublished - Nov 2018

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Infectious Diseases


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