Platelet activating factor and its metabolite promote sleep in rabbits

Tetsuya Kushikata, Jidong Fang, James M. Krueger

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Platelet activating factor (PAF) is a key inflammatory mediator. PAF and its receptor are found in brain and PAF affects or is affected by the production of sleep promoting cytokines such as interleukin-1. PAF also interacts with several other sleep-regulatory substances such as nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, nitric oxide, prostaglandins, and prolactin. We thus hypothesized that PAF would increase sleep. In these experiments, each rabbit received an injection of 25 μl of 2% DMSO to obtain control values, and on a separate day received PAF or lyso-PAF, a metabolite of PAF. Ten, 100 and 500 nmol for each substance was injected intracerebroventricularly. Both PAF and lyso-PAF enhanced non-rapid eye movement (NREM) sleep but not REM sleep. Lyso-PAF, but not PAF, induced hyperthermia. Results are consistent with the hypothesis that the brain cytokine network is involved in physiological sleep regulation.

Original languageEnglish (US)
Pages (from-to)233-238
Number of pages6
JournalNeuroscience letters
Issue number3
StatePublished - Feb 20 2006

All Science Journal Classification (ASJC) codes

  • General Neuroscience


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