Polyamines and neoplastic growth

Anthony Pegg, D. J. Feith

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


Studies over many years have suggested that increased polyamine synthesis may be necessary for neoplastic growth. This review summarizes recent work on the regulation of putrescine production both de novo and via the degradation of higher polyamines and provides a summary of studies using transgenic mice in which the levels of proteins that regulate these processes (L-ornithine decarboxylase, antizyme and spermidine/spermine-N1-acetyltransferase) are altered.

Original languageEnglish (US)
Pages (from-to)295-299
Number of pages5
JournalBiochemical Society transactions
Issue number2
StatePublished - Apr 2007

All Science Journal Classification (ASJC) codes

  • Biochemistry


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