Polyamines inhibit the yeast histone deacetylase

Quang A. Vu, Dong er Zhang, Zissis C. Chroneos, Daniel A. Nelson

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


n-Butyrate inhibits the histone deacetylase from higher cells, but has little effect on the enzyme activity in Saccharomyces cerevisiae. Spermine and spermidine were therefore tested as potential yeast deacetylase inhibitors and found to inhibit fully the enzyme at 2 and 5 mM, respectively. The utility of these inhibitors was demonstrated by showing that 2 mM spermine substantially increased the incorporation of [3H]acetate into histone in a yeast nuclear acetyltransferase assay.

Original languageEnglish (US)
Pages (from-to)79-83
Number of pages5
JournalFEBS Letters
Issue number1
StatePublished - Aug 10 1987

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


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