TY - JOUR
T1 - Polycyclic aromatic hydrocarbon reference range levels in the U.S. population by measurement of urinary mono-hydroxy metabolites
AU - Grainger, James
AU - Huang, Wenlin
AU - Li, Zheng
AU - Edwards, Selvin
AU - Walcott, Charisse
AU - Smith, Christopher
AU - Turner, Wayman
AU - Wang, Richard
AU - Patterson, Donald G.
PY - 2005/1/1
Y1 - 2005/1/1
N2 - We developed a gas chromatography/ isotope dilution high resolution mass spectrometry (GC/ID-HRMS) method for measuring 18 PAH metabolites representing 8 parent PAHs in 3 mL of urine at low part-per-trillion levels. We applied this method to the analysis of urine specimens from approximately 2400 people who participated in the National Health and Nutrition Examination Survey for the years 1999 and 2000 to determine levels for 14 PAH hydroxy metabolites of 7 parent compounds. Using this GC/ID-HRMS method, we found detectable concentrations for monohydroxy metabolite isomers fluorene, phenanthrene, fluoranthene, and pyrene, and for chrysene, benzo[c]phenanthrene, and benz[a]anthracene. Some mono-hydroxy metabolite isomers of chrysene, benzo[c]phenanthrene, and benz[a]anthracene exhibited low detection frequencies which did not allow for geometric mean calculations. From our study, we established a reference range for the targeted PAHs in the general U.S. population.
AB - We developed a gas chromatography/ isotope dilution high resolution mass spectrometry (GC/ID-HRMS) method for measuring 18 PAH metabolites representing 8 parent PAHs in 3 mL of urine at low part-per-trillion levels. We applied this method to the analysis of urine specimens from approximately 2400 people who participated in the National Health and Nutrition Examination Survey for the years 1999 and 2000 to determine levels for 14 PAH hydroxy metabolites of 7 parent compounds. Using this GC/ID-HRMS method, we found detectable concentrations for monohydroxy metabolite isomers fluorene, phenanthrene, fluoranthene, and pyrene, and for chrysene, benzo[c]phenanthrene, and benz[a]anthracene. Some mono-hydroxy metabolite isomers of chrysene, benzo[c]phenanthrene, and benz[a]anthracene exhibited low detection frequencies which did not allow for geometric mean calculations. From our study, we established a reference range for the targeted PAHs in the general U.S. population.
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U2 - 10.1080/104066390517927
DO - 10.1080/104066390517927
M3 - Article
AN - SCOPUS:13844281408
SN - 1040-6638
VL - 25
SP - 47
EP - 65
JO - Polycyclic Aromatic Compounds
JF - Polycyclic Aromatic Compounds
IS - 1
ER -