Polycystic kidney disease: Pathogenesis and potential therapies

Vinita Takiar; Michael J. Caplan

doi:10.1016/j.bbadis.2010.11.014

Polycystic kidney disease: Pathogenesis and potential therapies

Vinita Takiar
, Michael J. Caplan

Department of Radiation Oncology

Research output: Contribution to journal › Review article › peer-review

69 Scopus citations

Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is a prevalent, inherited condition for which there is currently no effective specific clinical therapy. The disease is characterized by the progressive development of fluid-filled cysts derived from renal tubular epithelial cells which gradually compress the parenchyma and compromise renal function. Current interests in the field focus on understanding and exploiting signaling mechanisms underlying disease pathogenesis as well as delineating the role of the primary cilium in cystogenesis. This review highlights the pathogenetic pathways underlying renal cyst formation as well as novel therapeutic targets for the treatment of PKD.

Original language	English (US)
Pages (from-to)	1337-1343
Number of pages	7
Journal	Biochimica et Biophysica Acta - Molecular Basis of Disease
Volume	1812
Issue number	10
DOIs	https://doi.org/10.1016/j.bbadis.2010.11.014
State	Published - Oct 2011

All Science Journal Classification (ASJC) codes

Molecular Medicine
Molecular Biology

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10.1016/j.bbadis.2010.11.014

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AB - Autosomal dominant polycystic kidney disease (ADPKD) is a prevalent, inherited condition for which there is currently no effective specific clinical therapy. The disease is characterized by the progressive development of fluid-filled cysts derived from renal tubular epithelial cells which gradually compress the parenchyma and compromise renal function. Current interests in the field focus on understanding and exploiting signaling mechanisms underlying disease pathogenesis as well as delineating the role of the primary cilium in cystogenesis. This review highlights the pathogenetic pathways underlying renal cyst formation as well as novel therapeutic targets for the treatment of PKD.

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DO - 10.1016/j.bbadis.2010.11.014

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Polycystic kidney disease: Pathogenesis and potential therapies

Abstract

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