TY - JOUR
T1 - Polymeric Framboidal Nanoparticles Loaded with a Carbon Monoxide Donor via Phenylboronic Acid-Catechol Complexation
AU - Van Der Vlies, André J.
AU - Inubushi, Ryosuke
AU - Uyama, Hiroshi
AU - Hasegawa, Urara
N1 - Publisher Copyright:
© 2016 American Chemical Society.
PY - 2016/6/15
Y1 - 2016/6/15
N2 - Carbon monoxide (CO) is an essential gaseous signaling molecule in the human body. Toward the controlled delivery of CO to the target tissues or cells, nanomaterial-based CO donors have attracted growing attention. Here, we present CO-releasing polymeric nanoparticles (CONPs) prepared by simple mixing of phenylboronic acid-containing framboidal nanoparticles with the catechol-bearing CO-donor Ru(CO)3Cl(L-DOPA) via phenylboronic acid-catechol complexation. The CONPs release CO in response to cysteine and suppress the production of the pro-inflammatory mediators interleukin 6 (IL-6) and nitric oxide (NO) in lipopolysaccharide (LPS)-stimulated murine macrophages. This CONP platform may show promise in therapeutic applications of CO.
AB - Carbon monoxide (CO) is an essential gaseous signaling molecule in the human body. Toward the controlled delivery of CO to the target tissues or cells, nanomaterial-based CO donors have attracted growing attention. Here, we present CO-releasing polymeric nanoparticles (CONPs) prepared by simple mixing of phenylboronic acid-containing framboidal nanoparticles with the catechol-bearing CO-donor Ru(CO)3Cl(L-DOPA) via phenylboronic acid-catechol complexation. The CONPs release CO in response to cysteine and suppress the production of the pro-inflammatory mediators interleukin 6 (IL-6) and nitric oxide (NO) in lipopolysaccharide (LPS)-stimulated murine macrophages. This CONP platform may show promise in therapeutic applications of CO.
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U2 - 10.1021/acs.bioconjchem.6b00135
DO - 10.1021/acs.bioconjchem.6b00135
M3 - Article
C2 - 27128363
AN - SCOPUS:84975165544
SN - 1043-1802
VL - 27
SP - 1500
EP - 1508
JO - Bioconjugate Chemistry
JF - Bioconjugate Chemistry
IS - 6
ER -