TY - JOUR
T1 - Polymeric microcarriers from PDLLA homopolymers and PDLLA/PEG copolymers as drug carriers
AU - Denkbas, E.
AU - Kaitian, X.
AU - Kozluca, A.
AU - Piskin, E.
PY - 1994/11
Y1 - 1994/11
N2 - Poly(DL-lactide)s (PDLLA) were prepared by ring opening polymerization, and then transesterified with polyethylene glycol (PEG). Polymeric particles with different sizes were produced by solvent evaporation, by stirring, and by sonication. The average size and size distribution were determined by SEM. A model drug, rifampicin, was loaded within these particles. Release from these matrices was studied in vitro. Higher rifampicin release rates were obtained from low molecular weight PDLLA-prepared particles which degraded faster.
AB - Poly(DL-lactide)s (PDLLA) were prepared by ring opening polymerization, and then transesterified with polyethylene glycol (PEG). Polymeric particles with different sizes were produced by solvent evaporation, by stirring, and by sonication. The average size and size distribution were determined by SEM. A model drug, rifampicin, was loaded within these particles. Release from these matrices was studied in vitro. Higher rifampicin release rates were obtained from low molecular weight PDLLA-prepared particles which degraded faster.
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M3 - Article
AN - SCOPUS:17644430901
SN - 1073-1199
VL - 22
JO - Artificial Cells, Blood Substitutes, and Immobilization Biotechnology
JF - Artificial Cells, Blood Substitutes, and Immobilization Biotechnology
IS - 5
ER -