Polymeric microcarriers from PDLLA homopolymers and PDLLA/PEG copolymers as drug carriers

E. Denkbas; X. Kaitian; A. Kozluca; E. Piskin

Polymeric microcarriers from PDLLA homopolymers and PDLLA/PEG copolymers as drug carriers

E. Denkbas
, X. Kaitian
, A. Kozluca
, E. Piskin

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

Poly(DL-lactide)s (PDLLA) were prepared by ring opening polymerization, and then transesterified with polyethylene glycol (PEG). Polymeric particles with different sizes were produced by solvent evaporation, by stirring, and by sonication. The average size and size distribution were determined by SEM. A model drug, rifampicin, was loaded within these particles. Release from these matrices was studied in vitro. Higher rifampicin release rates were obtained from low molecular weight PDLLA-prepared particles which degraded faster.

Original language	English (US)
Journal	Artificial Cells, Blood Substitutes, and Immobilization Biotechnology
Volume	22
Issue number	5
State	Published - Nov 1994

All Science Journal Classification (ASJC) codes

Biotechnology
Biomedical Engineering

Cite this

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title = "Polymeric microcarriers from PDLLA homopolymers and PDLLA/PEG copolymers as drug carriers",

abstract = "Poly(DL-lactide)s (PDLLA) were prepared by ring opening polymerization, and then transesterified with polyethylene glycol (PEG). Polymeric particles with different sizes were produced by solvent evaporation, by stirring, and by sonication. The average size and size distribution were determined by SEM. A model drug, rifampicin, was loaded within these particles. Release from these matrices was studied in vitro. Higher rifampicin release rates were obtained from low molecular weight PDLLA-prepared particles which degraded faster.",

author = "E. Denkbas and X. Kaitian and A. Kozluca and E. Piskin",

year = "1994",

month = nov,

language = "English (US)",

volume = "22",

journal = "Artificial Cells, Blood Substitutes, and Immobilization Biotechnology",

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T1 - Polymeric microcarriers from PDLLA homopolymers and PDLLA/PEG copolymers as drug carriers

AU - Denkbas, E.

AU - Kaitian, X.

AU - Kozluca, A.

AU - Piskin, E.

PY - 1994/11

Y1 - 1994/11

N2 - Poly(DL-lactide)s (PDLLA) were prepared by ring opening polymerization, and then transesterified with polyethylene glycol (PEG). Polymeric particles with different sizes were produced by solvent evaporation, by stirring, and by sonication. The average size and size distribution were determined by SEM. A model drug, rifampicin, was loaded within these particles. Release from these matrices was studied in vitro. Higher rifampicin release rates were obtained from low molecular weight PDLLA-prepared particles which degraded faster.

AB - Poly(DL-lactide)s (PDLLA) were prepared by ring opening polymerization, and then transesterified with polyethylene glycol (PEG). Polymeric particles with different sizes were produced by solvent evaporation, by stirring, and by sonication. The average size and size distribution were determined by SEM. A model drug, rifampicin, was loaded within these particles. Release from these matrices was studied in vitro. Higher rifampicin release rates were obtained from low molecular weight PDLLA-prepared particles which degraded faster.

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UR - https://www.scopus.com/pages/publications/17644430901#tab=citedBy

M3 - Article

AN - SCOPUS:17644430901

SN - 1073-1199

VL - 22

JO - Artificial Cells, Blood Substitutes, and Immobilization Biotechnology

JF - Artificial Cells, Blood Substitutes, and Immobilization Biotechnology

IS - 5

ER -

Polymeric microcarriers from PDLLA homopolymers and PDLLA/PEG copolymers as drug carriers

Abstract

All Science Journal Classification (ASJC) codes

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