Polymorphism of the HLA-DRB1 locus in Colombian, Ecuadorian and Chilean Amerinds

Nadezda Blagitko; Colm O'Huigin; Felipe Figueroa; Satoshi Horai; Sunro Sonoda; Kazuo Tajima; David Watkins; Jan Klein

doi:10.1016/S0198-8859(97)00005-0

Polymorphism of the HLA-DRB1 locus in Colombian, Ecuadorian and Chilean Amerinds

Nadezda Blagitko, Colm O'Huigin, Felipe Figueroa, Satoshi Horai, Sunro Sonoda, Kazuo Tajima, David Watkins, Jan Klein

Biology

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

We have characterized the DRB1 genotypes in a sample of 64 South American Indians drawn from populations in Chile, Colombia, and Ecuador. No novel DRB1 alleles were found in the total of 17 different alleles characterized, indicating that rapid allelic generation does not occur at the DRB1 loci, in contrast to HLA-B. Comparison between Chilean and Colombian/Ecuadorian samples revealed no major differences in their allelic frequencies. In the combined Amerind sample the HLA-DRB1*0407 and HLA- DRB1*1402 alleles occurred in the highest frequencies (38% and 22%, respectively). Genetic distance measurement showed the HLA-DRB1 frequencies reported here to agree with findings in other Amerind groups. The high frequencies of both HLA-DRB1*0407 and HLA-DRB1*1602 alleles, in conjunction with their absence in Siberian samples, suggest that migratory groups other than Siberians may have been involved in the peopling of the Americas.

Original language	English (US)
Pages (from-to)	74-81
Number of pages	8
Journal	Human Immunology
Volume	54
Issue number	1
DOIs	https://doi.org/10.1016/S0198-8859(97)00005-0
State	Published - Apr 15 1997

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology

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10.1016/S0198-8859(97)00005-0

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title = "Polymorphism of the HLA-DRB1 locus in Colombian, Ecuadorian and Chilean Amerinds",

abstract = "We have characterized the DRB1 genotypes in a sample of 64 South American Indians drawn from populations in Chile, Colombia, and Ecuador. No novel DRB1 alleles were found in the total of 17 different alleles characterized, indicating that rapid allelic generation does not occur at the DRB1 loci, in contrast to HLA-B. Comparison between Chilean and Colombian/Ecuadorian samples revealed no major differences in their allelic frequencies. In the combined Amerind sample the HLA-DRB1*0407 and HLA- DRB1*1402 alleles occurred in the highest frequencies (38% and 22%, respectively). Genetic distance measurement showed the HLA-DRB1 frequencies reported here to agree with findings in other Amerind groups. The high frequencies of both HLA-DRB1*0407 and HLA-DRB1*1602 alleles, in conjunction with their absence in Siberian samples, suggest that migratory groups other than Siberians may have been involved in the peopling of the Americas.",

author = "Nadezda Blagitko and Colm O'Huigin and Felipe Figueroa and Satoshi Horai and Sunro Sonoda and Kazuo Tajima and David Watkins and Jan Klein",

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T1 - Polymorphism of the HLA-DRB1 locus in Colombian, Ecuadorian and Chilean Amerinds

AU - Blagitko, Nadezda

AU - O'Huigin, Colm

AU - Figueroa, Felipe

AU - Horai, Satoshi

AU - Sonoda, Sunro

AU - Tajima, Kazuo

AU - Watkins, David

AU - Klein, Jan

PY - 1997/4/15

Y1 - 1997/4/15

N2 - We have characterized the DRB1 genotypes in a sample of 64 South American Indians drawn from populations in Chile, Colombia, and Ecuador. No novel DRB1 alleles were found in the total of 17 different alleles characterized, indicating that rapid allelic generation does not occur at the DRB1 loci, in contrast to HLA-B. Comparison between Chilean and Colombian/Ecuadorian samples revealed no major differences in their allelic frequencies. In the combined Amerind sample the HLA-DRB1*0407 and HLA- DRB1*1402 alleles occurred in the highest frequencies (38% and 22%, respectively). Genetic distance measurement showed the HLA-DRB1 frequencies reported here to agree with findings in other Amerind groups. The high frequencies of both HLA-DRB1*0407 and HLA-DRB1*1602 alleles, in conjunction with their absence in Siberian samples, suggest that migratory groups other than Siberians may have been involved in the peopling of the Americas.

AB - We have characterized the DRB1 genotypes in a sample of 64 South American Indians drawn from populations in Chile, Colombia, and Ecuador. No novel DRB1 alleles were found in the total of 17 different alleles characterized, indicating that rapid allelic generation does not occur at the DRB1 loci, in contrast to HLA-B. Comparison between Chilean and Colombian/Ecuadorian samples revealed no major differences in their allelic frequencies. In the combined Amerind sample the HLA-DRB1*0407 and HLA- DRB1*1402 alleles occurred in the highest frequencies (38% and 22%, respectively). Genetic distance measurement showed the HLA-DRB1 frequencies reported here to agree with findings in other Amerind groups. The high frequencies of both HLA-DRB1*0407 and HLA-DRB1*1602 alleles, in conjunction with their absence in Siberian samples, suggest that migratory groups other than Siberians may have been involved in the peopling of the Americas.

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Polymorphism of the HLA-DRB1 locus in Colombian, Ecuadorian and Chilean Amerinds

Abstract

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