TY - JOUR
T1 - Poly(p-phenylenevinylene) functionalized fluorescent mesoporous silica nanoparticles for drug release and cell imaging
AU - Qu, Ying
AU - Feng, Lijuan
AU - Tong, Cuiyan
AU - Liu, Bingxin
AU - Lü, Changli
N1 - Funding Information:
We would like to appreciate the financial support of the National Natural Science Foundation of China ( 21074019 ) and Natural Science Foundation of Jilin Province ( 20101539 ).
PY - 2013
Y1 - 2013
N2 - A fluorescent conjugated polymer of poly(p-phenylenevinylene) (PPV) was incorporated into the mesoporous silica nanoparticles (MSNs) by an ion-exchange and in situ polymerization route. The PPV functionalized MSNs were further coated with a layer of mesoporous silica shell to form the core-shell MSNs (PPV@MSN@nSiO2@mSiO2) by the controlled hydrolysis and condensation of silica precursor combining the in situ sol-gel process. The obtained fluorescent MSNs containing PPV were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), N2 adsorption/desorption and photoluminescence (PL) spectra. The results indicated that the novel containing-PPV MSNs had a diameter range of about 45-120 nm and a strong PL emission at 520 nm with a high fluorescent quantum yield (QY) up to 71%. The mesoporous features of fluorescence MSNs with or without core-shell structure imparted the capabilities of loading and releasing drug with a relatively high loading efficiency and a sustained release behavior of drugs. The investigations showed that these samples had a slow release effect of ibuprofen (IBU). In addition, the novel fluorescent MSNs were used in the in vitro researches of the imaging for human cervical cancer cells (HeLa).
AB - A fluorescent conjugated polymer of poly(p-phenylenevinylene) (PPV) was incorporated into the mesoporous silica nanoparticles (MSNs) by an ion-exchange and in situ polymerization route. The PPV functionalized MSNs were further coated with a layer of mesoporous silica shell to form the core-shell MSNs (PPV@MSN@nSiO2@mSiO2) by the controlled hydrolysis and condensation of silica precursor combining the in situ sol-gel process. The obtained fluorescent MSNs containing PPV were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), N2 adsorption/desorption and photoluminescence (PL) spectra. The results indicated that the novel containing-PPV MSNs had a diameter range of about 45-120 nm and a strong PL emission at 520 nm with a high fluorescent quantum yield (QY) up to 71%. The mesoporous features of fluorescence MSNs with or without core-shell structure imparted the capabilities of loading and releasing drug with a relatively high loading efficiency and a sustained release behavior of drugs. The investigations showed that these samples had a slow release effect of ibuprofen (IBU). In addition, the novel fluorescent MSNs were used in the in vitro researches of the imaging for human cervical cancer cells (HeLa).
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U2 - 10.1016/j.micromeso.2013.08.045
DO - 10.1016/j.micromeso.2013.08.045
M3 - Article
AN - SCOPUS:84884540859
SN - 1387-1811
VL - 182
SP - 155
EP - 164
JO - Microporous and Mesoporous Materials
JF - Microporous and Mesoporous Materials
ER -
