Polysaccharide Degradation by the Intestinal Microbiota and Its Influence on Human Health and Disease

Darrell W. Cockburn, Nicole M. Koropatkin

Research output: Contribution to journalReview articlepeer-review

367 Scopus citations


Carbohydrates comprise a large fraction of the typical diet, yet humans are only able to directly process some types of starch and simple sugars. The remainder transits the large intestine where it becomes food for the commensal bacterial community. This is an environment of not only intense competition but also impressive cooperation for available glycans, as these bacteria work to maximize their energy harvest from these carbohydrates during their limited transit time through the gut. The species within the gut microbiota use a variety of strategies to process and scavenge both dietary and host-produced glycans such as mucins. Some act as generalists that are able to degrade a wide range of polysaccharides, while others are specialists that are only able to target a few select glycans. All are members of a metabolic network where substantial cross-feeding takes place, as by-products of one organism serve as important resources for another. Much of this metabolic activity influences host physiology, as secondary metabolites and fermentation end products are absorbed either by the epithelial layer or by transit via the portal vein to the liver where they can have additional effects. These microbially derived compounds influence cell proliferation and apoptosis, modulate the immune response, and can alter host metabolism. This review summarizes the molecular underpinnings of these polysaccharide degradation processes, their impact on human health, and how we can manipulate them through the use of prebiotics.

Original languageEnglish (US)
Pages (from-to)3230-3252
Number of pages23
JournalJournal of Molecular Biology
Issue number16
StatePublished - Aug 14 2016

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Molecular Biology


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