Polyurethanes in cardiac device leads: Effect of morphology on performance

Aiay D. Padsalgikar; Genevieve Gallagher; Elizabeth Cosgriff-Hernandez; James Runt

Polyurethanes in cardiac device leads: Effect of morphology on performance

Aiay D. Padsalgikar, Genevieve Gallagher, Elizabeth Cosgriff-Hernandez, James Runt

Research output: Contribution to conference › Paper › peer-review

Abstract

Implantable thermoplastic polyurethanes (TPU) have been utilized in the medical industry for decades due to their combination of biocompatibility, abrasion resistance, and processability. The present review attempts to establish the main factors that affect the long term biostability of TPUs, based upon multiple in vitro and in vivo studies. TPUs present two main degradation modes: oxidation and hydrolysis, which accelerate under mechanical stress. Siloxane-based TPUs seem to be most resistant to biological degradation. In addition, their complex morphology makes accelerated in vitro predictions based on time-temperature superposition inaccurate.

Original language	English (US)
Pages	1893-1899
Number of pages	7
State	Published - 2014
Event	72nd Annual Technical Conference of the Society of Plastics Engineers: The Plastics Conference, ANTEC 2014 - Las Vegas, United States Duration: Apr 28 2014 → Apr 30 2014

Other

Other	72nd Annual Technical Conference of the Society of Plastics Engineers: The Plastics Conference, ANTEC 2014
Country/Territory	United States
City	Las Vegas
Period	4/28/14 → 4/30/14

All Science Journal Classification (ASJC) codes

General Chemical Engineering
Polymers and Plastics

Cite this

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title = "Polyurethanes in cardiac device leads: Effect of morphology on performance",

abstract = "Implantable thermoplastic polyurethanes (TPU) have been utilized in the medical industry for decades due to their combination of biocompatibility, abrasion resistance, and processability. The present review attempts to establish the main factors that affect the long term biostability of TPUs, based upon multiple in vitro and in vivo studies. TPUs present two main degradation modes: oxidation and hydrolysis, which accelerate under mechanical stress. Siloxane-based TPUs seem to be most resistant to biological degradation. In addition, their complex morphology makes accelerated in vitro predictions based on time-temperature superposition inaccurate.",

author = "Padsalgikar, {Aiay D.} and Genevieve Gallagher and Elizabeth Cosgriff-Hernandez and James Runt",

year = "2014",

language = "English (US)",

pages = "1893--1899",

note = "72nd Annual Technical Conference of the Society of Plastics Engineers: The Plastics Conference, ANTEC 2014 ; Conference date: 28-04-2014 Through 30-04-2014",

}

Polyurethanes in cardiac device leads: Effect of morphology on performance. / Padsalgikar, Aiay D.; Gallagher, Genevieve; Cosgriff-Hernandez, Elizabeth et al.
2014. 1893-1899 Paper presented at 72nd Annual Technical Conference of the Society of Plastics Engineers: The Plastics Conference, ANTEC 2014, Las Vegas, United States.

Research output: Contribution to conference › Paper › peer-review

TY - CONF

T1 - Polyurethanes in cardiac device leads

T2 - 72nd Annual Technical Conference of the Society of Plastics Engineers: The Plastics Conference, ANTEC 2014

AU - Padsalgikar, Aiay D.

AU - Gallagher, Genevieve

AU - Cosgriff-Hernandez, Elizabeth

AU - Runt, James

PY - 2014

Y1 - 2014

N2 - Implantable thermoplastic polyurethanes (TPU) have been utilized in the medical industry for decades due to their combination of biocompatibility, abrasion resistance, and processability. The present review attempts to establish the main factors that affect the long term biostability of TPUs, based upon multiple in vitro and in vivo studies. TPUs present two main degradation modes: oxidation and hydrolysis, which accelerate under mechanical stress. Siloxane-based TPUs seem to be most resistant to biological degradation. In addition, their complex morphology makes accelerated in vitro predictions based on time-temperature superposition inaccurate.

AB - Implantable thermoplastic polyurethanes (TPU) have been utilized in the medical industry for decades due to their combination of biocompatibility, abrasion resistance, and processability. The present review attempts to establish the main factors that affect the long term biostability of TPUs, based upon multiple in vitro and in vivo studies. TPUs present two main degradation modes: oxidation and hydrolysis, which accelerate under mechanical stress. Siloxane-based TPUs seem to be most resistant to biological degradation. In addition, their complex morphology makes accelerated in vitro predictions based on time-temperature superposition inaccurate.

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M3 - Paper

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Y2 - 28 April 2014 through 30 April 2014

ER -

Polyurethanes in cardiac device leads: Effect of morphology on performance

Abstract

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All Science Journal Classification (ASJC) codes

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