TY - JOUR
T1 - Pontine and thalamic influences on fluid rewards
T2 - III. Anticipatory contrast for sucrose and corn oil
AU - Liang, Nu Chu
AU - Norgren, Ralph
AU - Grigson, Patricia S.
N1 - Funding Information:
The authors thank Dr. Chris Freet for writing the computer programs for the ACE experiments, Han Li for making brain lesions, and Kathy Matayas and Nellie Horvath for histology. This study was supported by grant DK079182 , DC00240 , and DA012473 from the National Institute of Health , as well as a PA State Tobacco Settlement Award .
PY - 2012/1/18
Y1 - 2012/1/18
N2 - An anticipatory contrast effect (ACE) occurs when, across daily trials, an animal comes to respond less than normally to a first stimulus when it is followed shortly by a second, more preferred solution. Classically, ACE is studied using a low (L) concentration of saccharin or sucrose, followed by access to a higher (H) concentration of sucrose. Subjects in the control condition have two bouts of access to the weaker solution presented on the same schedule. The ACE is measured by the difference in intake of the first bout low solution between subjects in the low-low (L-L) vs. the low-high (L-H) conditions. Here we used this paradigm with sham feeding rats and determined that nutritional feedback was unnecessary for the development of ACE with two concentrations of sucrose or with two concentrations of corn oil. Next we showed that ibotenic acid lesions centered in the orosensory thalamus spared ACEs for both sucrose and corn oil. In contrast, lesions of the pontine parabrachial nuclei (PBN), the second central relay for taste in the rat, disrupted ACEs for both sucrose and corn oil. Although the sensory modalities needed for the oral detection of fats remain controversial, it appears that the PBN is involved in processing the comparison of disparate concentrations of sucrose and oil reward.
AB - An anticipatory contrast effect (ACE) occurs when, across daily trials, an animal comes to respond less than normally to a first stimulus when it is followed shortly by a second, more preferred solution. Classically, ACE is studied using a low (L) concentration of saccharin or sucrose, followed by access to a higher (H) concentration of sucrose. Subjects in the control condition have two bouts of access to the weaker solution presented on the same schedule. The ACE is measured by the difference in intake of the first bout low solution between subjects in the low-low (L-L) vs. the low-high (L-H) conditions. Here we used this paradigm with sham feeding rats and determined that nutritional feedback was unnecessary for the development of ACE with two concentrations of sucrose or with two concentrations of corn oil. Next we showed that ibotenic acid lesions centered in the orosensory thalamus spared ACEs for both sucrose and corn oil. In contrast, lesions of the pontine parabrachial nuclei (PBN), the second central relay for taste in the rat, disrupted ACEs for both sucrose and corn oil. Although the sensory modalities needed for the oral detection of fats remain controversial, it appears that the PBN is involved in processing the comparison of disparate concentrations of sucrose and oil reward.
UR - http://www.scopus.com/inward/record.url?scp=82155185271&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=82155185271&partnerID=8YFLogxK
U2 - 10.1016/j.physbeh.2011.06.008
DO - 10.1016/j.physbeh.2011.06.008
M3 - Article
C2 - 21703289
AN - SCOPUS:82155185271
SN - 0031-9384
VL - 105
SP - 595
EP - 606
JO - Physiology and Behavior
JF - Physiology and Behavior
IS - 2
ER -