TY - JOUR
T1 - Population data for 101 Austrian Caucasian mitochondrial DNA d-loop sequences
T2 - Application of mtDNA sequence analysis to a forensic case
AU - Parson, W.
AU - Parsons, T. J.
AU - Scheithauer, R.
AU - Holland, M. M.
PY - 1998/4
Y1 - 1998/4
N2 - The sequence of the two hypervariable segments of the mitochondrial DNA (mtDNA) control region was generated for 101 random Austrian Caucasians. A total of 86 different mtDNA sequences was observed, where 11 sequences were shared by more than 1 individual, 7 sequences were shared by 2 individuals and 4 sequences were shared by 3 individuals. One of the four most common mtDNA sequences in Austrians is also the most common sequence in both U.S. and British Caucasians, found in approximately 3.0% of Austrians, 4.0% of British, and 3.9% of U.S. Caucasians. Of the remaining three common Austrian sequences, one was not observed in either U.S. or British Caucasians. However, three British Caucasians exhibited a similar sequence type. Therefore, this particular cluster of sequence polymorphisms may represent a common 'European' mtDNA sequence type. In general, Austrian Caucasians show little deviation from other Caucasian databases of European descent. Finally mtDNA sequence analysis was applied to a forensic case, where hairs found at a crime scene matched the control hairs from the suspect.
AB - The sequence of the two hypervariable segments of the mitochondrial DNA (mtDNA) control region was generated for 101 random Austrian Caucasians. A total of 86 different mtDNA sequences was observed, where 11 sequences were shared by more than 1 individual, 7 sequences were shared by 2 individuals and 4 sequences were shared by 3 individuals. One of the four most common mtDNA sequences in Austrians is also the most common sequence in both U.S. and British Caucasians, found in approximately 3.0% of Austrians, 4.0% of British, and 3.9% of U.S. Caucasians. Of the remaining three common Austrian sequences, one was not observed in either U.S. or British Caucasians. However, three British Caucasians exhibited a similar sequence type. Therefore, this particular cluster of sequence polymorphisms may represent a common 'European' mtDNA sequence type. In general, Austrian Caucasians show little deviation from other Caucasian databases of European descent. Finally mtDNA sequence analysis was applied to a forensic case, where hairs found at a crime scene matched the control hairs from the suspect.
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U2 - 10.1007/s004140050132
DO - 10.1007/s004140050132
M3 - Article
C2 - 9587794
AN - SCOPUS:0031970150
SN - 0937-9827
VL - 111
SP - 124
EP - 132
JO - International Journal of Legal Medicine
JF - International Journal of Legal Medicine
IS - 3
ER -